Evidence map›Paper›PMID 36231770›Full record

ArticleInternational journal of environmental research and public health2022

Genetic Analysis Implicates Dysregulation of

Chi-Fen Chang, Shu-Pin Huang, Yu-Mei Hsueh, Jiun-Hung Geng, Chao-Yuan Huang, Bo-Ying Bao

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Chi-Fen ChangDepartment of Anatomy, School of Medicine, China Medical University, Taichung 406, Taiwan.
Shu-Pin HuangDepartment of Urology, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
Yu-Mei HsuehDepartment of Family Medicine, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan.ORCID 0000-0001-6113-9936
Jiun-Hung GengDepartment of Urology, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
Chao-Yuan HuangDepartment of Urology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei 100, Taiwan.
Bo-Ying BaoDepartment of Pharmacy, China Medical University, Taichung 406, Taiwan.ORCID 0000-0001-5510-6513
Kaohsiung Medical University · TWAsia University · TWChina Medical University · TWNational Taiwan University Hospital · TWWan Fang Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SH3 and multiple ankyrin repeat domains (SHANK) is a family of scaffold proteins that were first identified to be involved in balancing synaptic transmission via regulation of intracellular signalling crosstalk and have been linked to various cancers. However, the role of the SHANK genes in renal cell carcinoma (RCC) remains to be elucidated. In this study, we aimed to evaluate whether genetic variants in SHANK family genes affect the risk of RCC and survival of patients. A genetic association study was conducted using logistic regression and Cox regression analyses, followed by the correction for a false discovery rate (FDR), in 630 patients with RCC and controls. A pooled analysis was further performed to summarise the clinical relevance of

Indexed as

Carcinoma, Renal CellKidney NeoplasmsAllelesGenetic TestingHumansNerve Tissue ProteinsPolymorphism, Single NucleotideNerve Tissue ProteinsSHANK2 protein, humanrenal cell carcinomariskSHANKsingle-nucleotide polymorphismsurvival

Identifiers

PMID36231770
PMCPMC9566262
OpenAlexW4303685938

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.