Evidence map›Paper›PMID 36231131›Full record

ArticleCells2022

The Flavone Cirsiliol from

Lavinia Carlini, Gabriele Tancreda, Valeria Iobbi, Federico Caicci, Silvia Bruno, Alfonso Esposito, Daniela Calzia, Stefano Benini, Angela Bisio, Lucia Manni and 4 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Antioxidant and Hepatoprotective Potential ofInternational journal of molecular sciences · 2023
    Article
  8. International journal of environmental research and public health · 2023
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Lavinia CarliniFaculty of Science and Technology, Free University of Bolzano, 39100 Bolzano, Italy.ORCID 0000-0002-2153-3039
Gabriele TancredaDipartimento di Farmacia (DIFAR), University of Genoa, 16132 Genova, Italy.
Valeria IobbiDipartimento di Farmacia (DIFAR), University of Genoa, 16132 Genova, Italy.
Federico CaicciDepartment of Biology, Università di Padova, 35121 Padova, Italy.ORCID 0000-0001-6981-449X
Silvia BrunoDepartment of Experimental Medicine, University of Genoa, 16132 Genoa, Italy.
Alfonso EspositoInternational Centre for Genetic Engineering and Biotechnology (ICGEB), 34149 Trieste, Italy.ORCID 0000-0003-0726-5290
Daniela CalziaDipartimento di Farmacia (DIFAR), University of Genoa, 16132 Genova, Italy.
Stefano BeniniFaculty of Science and Technology, Free University of Bolzano, 39100 Bolzano, Italy.ORCID 0000-0001-6299-888X
Angela BisioDipartimento di Farmacia (DIFAR), University of Genoa, 16132 Genova, Italy.ORCID 0000-0002-7559-7732
Lucia ManniDepartment of Biology, Università di Padova, 35121 Padova, Italy.
Anna SchitoSezione di Microbiologia, Dipartimento di Scienze Chirurgiche e Diagnostiche Integrate (DISC), Università di Genova, 16145 Genova, Italy.
Carlo Enrico TraversoClinica Oculistica (DINOGMI), University of Genoa, 16132 Genova, Italy.
Silvia RaveraDepartment of Experimental Medicine, University of Genoa, 16132 Genoa, Italy.ORCID 0000-0002-0803-1042
Isabella PanfoliDipartimento di Farmacia (DIFAR), University of Genoa, 16132 Genova, Italy.ORCID 0000-0002-6261-1128
University of Genoa · ITFree University of Bozen-Bolzano · ITUniversity of Padua · ITInternational Centre for Genetic Engineering and Biotechnology · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several studies have shown that mammalian retinal rod outer segments (OS) are peculiar structures devoid of mitochondria, characterized by ectopic expression of the molecular machinery for oxidative phosphorylation. Such ectopic aerobic metabolism would provide the chemical energy for the phototransduction taking place in the OS. Natural polyphenols include a large variety of molecules having pleiotropic effects, ranging from anti-inflammatory to antioxidant and others. Our goal in the present study was to investigate the potential of the flavonoid cirsiliol, a trihydroxy-6,7-dimethoxyflavone extracted from

Indexed as

FlavonesSalviaAdenosine TriphosphateAnimalsAntioxidantsFree RadicalsHydrogen PeroxideMammalsMolecular Docking SimulationReactive Oxygen SpeciesAdenosine TriphosphateAntioxidantscirsiliolFlavonesFree RadicalsHydrogen PeroxideReactive Oxygen SpeciescirsiliolF1Fo-ATP synthaselightoxidative phosphorylationquercetinrespiratory chain complexesresveratrolrod outer segmenttransmission electron microscopy

Identifiers

PMID36231131
PMCPMC9562182
OpenAlexW4303946519

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.