Evidence map›Paper›PMID 36231087›Full record

ArticleCells2022

COVID-19 Pathology in the Lung, Kidney, Heart and Brain: The Different Roles of T-Cells, Macrophages, and Microthrombosis.

Tino Emanuele Poloni, Matteo Moretti, Valentina Medici, Elvira Turturici, Giacomo Belli, Elena Cavriani, Silvia Damiana Visonà, Michele Rossi, Valentina Fantini, Riccardo Rocco Ferrari and 5 more

Abstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Human brain matters: Navigating the neuropathology of COVID-19.Brain pathology (Zurich, Switzerland) · 2026
    Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Clinical features of COVID-19-related encephalitis: comparison with the features of herpes virus encephalitis and autoimmune encephalitis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Article
  7. Article
  8. Article
  9. Postmortem neuropathology in COVID-19: An update.Brain pathology (Zurich, Switzerland) · 2023
    Article
  10. COVID-19, Myocarditis and Pericarditis.Circulation research · 2023
    Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Tino Emanuele PoloniDepartment of Neurology and Neuropathology, Golgi-Cenci Foundation, Abbiategrasso, 20081 Milan, Italy.ORCID 0000-0002-8463-6879
Matteo MorettiDepartment of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy.ORCID 0000-0001-7420-9366
Valentina MediciDepartment of Neurology and Neuropathology, Golgi-Cenci Foundation, Abbiategrasso, 20081 Milan, Italy.ORCID 0000-0001-9385-3384
Elvira TurturiciDepartment of Neurology and Neuropathology, Golgi-Cenci Foundation, Abbiategrasso, 20081 Milan, Italy.
Giacomo BelliDepartment of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy.
Elena CavrianiDepartment of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy.
Silvia Damiana VisonàDepartment of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy.
Michele RossiUnit of Biostatistics, Golgi-Cenci Foundation, Abbiategrasso, 20081 Milan, Italy.
Valentina FantiniLaboratory of Neurobiology and Neurogenetic, Golgi-Cenci Foundation, Abbiategrasso, 20081 Milan, Italy.ORCID 0000-0003-1244-4453
Riccardo Rocco FerrariLaboratory of Neurobiology and Neurogenetic, Golgi-Cenci Foundation, Abbiategrasso, 20081 Milan, Italy.
Arenn Faye CarlosDepartment of Neurology and Neuropathology, Golgi-Cenci Foundation, Abbiategrasso, 20081 Milan, Italy.
Stella GagliardiUnit of Molecular Biology and Transcriptomics IRCCS Mondino Foundation, 27100 Pavia, Italy.ORCID 0000-0002-6589-6907
Livio TronconiDepartment of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy.
Antonio GuaitaDepartment of Neurology and Neuropathology, Golgi-Cenci Foundation, Abbiategrasso, 20081 Milan, Italy.ORCID 0000-0003-3954-5932
Mauro CeroniDepartment of Neurology and Neuropathology, Golgi-Cenci Foundation, Abbiategrasso, 20081 Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here, we aim to describe COVID-19 pathology across different tissues to clarify the disease's pathophysiology. Lungs, kidneys, hearts, and brains from nine COVID-19 autopsies were compared by using antibodies against SARS-CoV-2, macrophages-microglia, T-lymphocytes, B-lymphocytes, and activated platelets. Alzheimer's Disease pathology was also assessed. PCR techniques were used to verify the presence of viral RNA. COVID-19 cases had a short clinical course (0-32 days) and their mean age was 77.4 y/o. Hypoxic changes and inflammatory infiltrates were present across all tissues. The lymphocytic component in the lungs and kidneys was predominant over that of other tissues (

Indexed as

COVID-19ThrombosisAgedAntigens, ViralBrainHumansKidneyLungMacrophagesRNA, ViralSARS-CoV-2T-LymphocytesAntigens, ViralRNA, ViralbrainCOVID-19elderlyheartinflammationkidneylungneuropathologySARS-CoV-2

Identifiers

PMID36231087
PMCPMC9563269

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.