Evidence map›Paper›PMID 36231061›Full record

ArticleCells2022

Illustration of Gut-Thyroid Axis in Alcohol Use Disorder: Interplay of Gut Dysfunction, Pro-Inflammatory Responses, and Thyroid Function.

Manasa Sagaram, Amor J Royer, Huirong Hu, Abhas Rajhans, Ranganathan Parthasarathy, Sathya Sridevi Krishnasamy, Sri Prakash Mokshagundam, Maiying Kong, Melanie L Schwandt, Dipendra Parajuli and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Manasa SagaramDivision of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Louisville, Louisville, KY 40202, USA.
Amor J RoyerDivision of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Louisville, Louisville, KY 40202, USA.
Huirong HuClinical Laboratory for the Intervention Development of AUD and Organ Severity, University of Louisville, Louisville, KY 40202, USA.
Abhas RajhansClinical Laboratory for the Intervention Development of AUD and Organ Severity, University of Louisville, Louisville, KY 40202, USA.
Ranganathan ParthasarathyDivision of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Louisville, Louisville, KY 40202, USA.
Sathya Sridevi KrishnasamyDivision of Endocrinology, Metabolism & Diabetes, University of Louisville, Louisville, KY 40202, USA.
Sri Prakash MokshagundamDivision of Endocrinology, Metabolism & Diabetes, University of Louisville, Louisville, KY 40202, USA.
Maiying KongDepartment of Bioinformatics and Biostatistics, University of Louisville, Louisville, KY 40202, USA.
Melanie L SchwandtNational Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA.
Dipendra ParajuliDivision of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Louisville, Louisville, KY 40202, USA.
Matthew C CaveDivision of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Louisville, Louisville, KY 40202, USA.ORCID 0000-0002-2560-6696
Vatsalya VatsalyaDivision of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Louisville, Louisville, KY 40202, USA.ORCID 0000-0001-6764-6891
University of Louisville · USNational Institute on Alcohol Abuse and Alcoholism · US

Funding

Lactobacillus rhamnosus: A Novel Probiotic Therapy for treating Alcohol Use DisorderK23AA029198 · NIAAA · UNIVERSITY OF LOUISVILLE · PI VATSALYA, VATSALYA · 2021 to 2025
$704k
Identification of Proteins from Mass Spectrometry Data: A Statistical ApproachR15CA170091 · NCI · UNIVERSITY OF LOUISVILLE · PI KONG, MAIYING · 2013 to 2013
$464k
NCI NIH HHS R15 CA170091NIAAA NIH HHS K23 AA029198
6 · The paper itself

Abstract

(1) Background: Heavy and chronic alcohol drinking leads to altered gut dysfunction, coupled with a pro-inflammatory state. Thyroid-associated hormones and proteins may be dysregulated by heavy and chronic alcohol intake; however, the mechanism for altered gut-derived changes in thyroid function has not been studied thus far. This study investigates the role of alcohol-induced gut dysfunction and pro-inflammatory cytokine profile in the thyroid function of patients with alcohol use disorder (AUD). (2) Methods: Male and female AUD patients (

Indexed as

AlcoholismIntestinesThyroid GlandAlcohol DrinkingCytokinesFemaleHumansInterleukin-1betaInterleukin-6Interleukin-8Lipopolysaccharide ReceptorsLipopolysaccharidesMalePlasminogen Activator Inhibitor 1Thyroid HormonesThyrotropinCytokinesInterleukin-1betaInterleukin-6Interleukin-8Lipopolysaccharide ReceptorsLipopolysaccharidesPlasminogen Activator Inhibitor 1Thyroid HormonesThyrotropinThyroxineTriiodothyronineTumor Necrosis Factor-alphaalcohol use disordergut dysfunctiongut–thyroid axispro-inflammatory cytokinesthyroid-associated hormones

Identifiers

PMID36231061
PMCPMC9563601
OpenAlexW4303629002

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.