Evidence map›Paper›PMID 36231010›Full record

ArticleCells2022

Thyroid Hormone Induces Oral Cancer Growth via the PD-L1-Dependent Signaling Pathway.

Kuan-Wei Su, Hung-Yun Lin, Hsien-Chung Chiu, Shin-Yu Shen, Chun A ChangOu, Dana R Crawford, Yu-Chen S H Yang, Ya-Jung Shih, Zi-Lin Li, Haw-Ming Huang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Integrin αvβ3 is a Potential Therapeutic Target in Cholangiocarcinoma.International journal of medical sciences · 2026
    Article
  4. Article
  5. Observational
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Kuan-Wei SuDepartment of Dentistry, Hsinchu MacKay Memorial Hospital, Hsinchu City 30071, Taiwan.
Hung-Yun LinGraduate Institute of Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0003-2824-6419
Hsien-Chung ChiuDepartment of Periodontology, School of Dentistry, National Defense Medical Center and Tri-Service General Hospital, Taipei 11490, Taiwan.
Shin-Yu ShenGraduate Institute of Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.
Chun A ChangOuCore Facility, Taipei Medical University, Taipei 11031, Taiwan.
Dana R CrawfordDepartment of Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA.
Yu-Chen S H YangJoint Biobank, Office of Human Research, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0002-7589-8527
Ya-Jung ShihGraduate Institute of Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.
Zi-Lin LiGraduate Institute of Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.
Haw-Ming HuangSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0003-4184-3744
Jaqueline Whang-PengCancer Center, Wan Fang Hospital, Taipei Medical University, Taipei 11031, Taiwan.
Yih HoSchool of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan.
Kuan WangGraduate Institute of Nanomedicine and Medical Engineering, College of Medical Engineering, Taipei Medical University, Taipei 11031, Taiwan.
Taipei Medical University · TWAlbany Medical Center Hospital · USMackay Memorial Hospital · TWTaipei Medical University Hospital · TWTri-Service General Hospital · TWWan Fang Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral cancer is a fatal disease, and its incidence in Taiwan is increasing. Thyroid hormone as L-thyroxine (T

Indexed as

B7-H1 AntigenMouth Neoplasmsbeta CateninHumansIntegrin alphaVbeta3Nuclear ProteinsRNA, Small InterferingSignal TransductionSTAT3 Transcription FactorThyroid HormonesThyroxineB7-H1 Antigenbeta CateninCD274 protein, humanIntegrin alphaVbeta3Nuclear ProteinsRNA, Small InterferingSTAT3 Transcription FactorThyroid HormonesThyroxineoral cancerPD-L1thyroxineβ-catenin

Identifiers

PMID36231010
PMCPMC9563246
OpenAlexW4298003093

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.