Evidence map›Paper›PMID 36230980›Full record

ArticleCells2022

Hedgehog Signaling as a Therapeutic Target for Airway Remodeling and Inflammation in Allergic Asthma.

Anthony Tam, Emmanuel Twumasi Osei, Chung Y Cheung, Michael Hughes, Chen X Yang, Kelly M McNagny, Delbert R Dorscheid, Gurpreet K Singhera, Teal S Hallstrand, Stephanie Warner and 4 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Astragalus polysaccharide mitigates the airway inflammation in bronchial asthma by regulating Hedgehog/NLRP3/GSDMD pathway.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. iScience · 2024
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Anthony TamCentre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC V6Z 1Y6, Canada.
Emmanuel Twumasi OseiCentre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC V6Z 1Y6, Canada.ORCID 0000-0002-4682-4422
Chung Y CheungCentre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC V6Z 1Y6, Canada.
Michael HughesSchool of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.ORCID 0000-0002-7925-6070
Chen X YangCentre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC V6Z 1Y6, Canada.
Kelly M McNagnyCentre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC V6Z 1Y6, Canada.ORCID 0000-0003-4737-3499
Delbert R DorscheidCentre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC V6Z 1Y6, Canada.
Gurpreet K SingheraCentre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC V6Z 1Y6, Canada.ORCID 0000-0002-8422-0857
Teal S HallstrandDivision of Pulmonary, Critical Care, Sleep Medicine and the Center for Lung Biology, University of Washington, Seattle, WA 98195-6522, USA.
Stephanie WarnerCentre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC V6Z 1Y6, Canada.
James C HoggCentre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC V6Z 1Y6, Canada.
Tillie L HackettCentre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC V6Z 1Y6, Canada.ORCID 0000-0001-7134-3287
Chinten J LimDepartment of Pediatrics, University of British Columbia, Vancouver, BC V6H 0B3, Canada.ORCID 0000-0001-6381-7585
Don D SinCentre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC V6Z 1Y6, Canada.ORCID 0000-0002-0756-6643
St. Paul's Hospital · CAUniversity of British Columbia · CAUniversity of Washington · US

Funding

CIHR 332196
6 · The paper itself

Abstract

Genome-wide association studies (GWAS) have shown that variants of patched homolog 1 (

Indexed as

Airway RemodelingAsthmaAnimalsDermatophagoides pteronyssinusGenome-Wide Association StudyHedgehog ProteinsHumansInflammationLigandsMatrix Metalloproteinase 2MiceMice, Inbred C57BLPatched-1 ReceptorPhosphatesPyroglyphidaeRNA, Small InterferingHedgehog ProteinsLigandsMatrix Metalloproteinase 2Patched-1 ReceptorPhosphatesRNA, Small InterferingTransforming Growth Factor beta1Zinc Finger Protein GLI1airway remodelingasthmahedgehog signalinginflammationTGFβ

Identifiers

PMID36230980
PMCPMC9562640
OpenAlexW4297348341

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.