Evidence map›Paper›PMID 36230793›Full record

ReviewCancers2022

Oncologic Imaging and Radiomics: A Walkthrough Review of Methodological Challenges.

Arnaldo Stanzione, Renato Cuocolo, Lorenzo Ugga, Francesco Verde, Valeria Romeo, Arturo Brunetti, Simone Maurea

Abstract readReview
In one paragraph

Review in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Arnaldo StanzioneDepartment of Advanced Biomedical Sciences, University of Naples "Federico II", 80131 Naples, Italy.ORCID 0000-0002-7905-5789
Renato CuocoloDepartment of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy.ORCID 0000-0002-1452-1574
Lorenzo UggaDepartment of Advanced Biomedical Sciences, University of Naples "Federico II", 80131 Naples, Italy.ORCID 0000-0001-7811-4612
Francesco VerdeDepartment of Advanced Biomedical Sciences, University of Naples "Federico II", 80131 Naples, Italy.ORCID 0000-0002-9823-4678
Valeria RomeoDepartment of Advanced Biomedical Sciences, University of Naples "Federico II", 80131 Naples, Italy.ORCID 0000-0002-1603-6396
Arturo BrunettiDepartment of Advanced Biomedical Sciences, University of Naples "Federico II", 80131 Naples, Italy.ORCID 0000-0001-7057-3494
Simone MaureaDepartment of Advanced Biomedical Sciences, University of Naples "Federico II", 80131 Naples, Italy.ORCID 0000-0002-8269-3765

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Imaging plays a crucial role in the management of oncologic patients, from the initial diagnosis to staging and treatment response monitoring. Recently, it has been suggested that its importance could be further increased by accessing a new layer of previously hidden quantitative data at the pixel level. Using a multi-step process, radiomics extracts potential biomarkers from medical images that could power decision support tools. Despite the growing interest and rising number of research articles being published, radiomics is still far from fulfilling its promise of guiding oncologic imaging toward personalized medicine. This is, at least partly, due to the heterogeneous methodological quality in radiomic research, caused by the complexity of the analysis pipelines. In this review, we aim to disentangle this complexity with a stepwise approach. Specifically, we focus on challenges to face during image preprocessing and segmentation, how to handle imbalanced classes and avoid information leaks, as well as strategies for the proper validation of findings.

Indexed as

evidence-based medicineoncologic imagingradiomicsreproducibilityresearch quality

Identifiers

PMID36230793
PMCPMC9562166

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.