Evidence map›Paper›PMID 36230777›Full record

ArticleCancers2022

Large Improvements in Health-Related Quality of Life and Physical Fitness during Multidisciplinary Inpatient Rehabilitation for Pediatric Cancer Survivors.

David Riedl, Thomas Licht, Alain Nickels, Maria Rothmund, Gerhard Rumpold, Bernhard Holzner, Vincent Grote, Michael J Fischer, Gustav Fischmeister

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06813950 (IMPACT of a PHYSICAL ACTIVITY PROGRAM on the HEALTH-RELATED QUALITY of LIFE in PEDIATRIC CANCER PATIENTS), which is not on this map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
7.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06813950 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

IMPACT of a PHYSICAL ACTIVITY PROGRAM on the HEALTH-RELATED QUALITY of LIFE in PEDIATRIC CANCER PATIENTS

TypeinterventionalSponsorSociedad de Lucha Contra el CáncerRan2025 to 2025Enrolled80ConditionsCancer, Pediatric CancerArmsPhysical activity
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
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  4. Article
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  6. Self-Concept in Pediatric Cancer Patients.Advances in experimental medicine and biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

David RiedlLudwig Boltzmann Institute for Rehabilitation Research, 1100 Vienna, Austria.ORCID 0000-0003-0518-3144
Thomas LichtPediatric Rehabilitation Center Leuwaldhof, 5621 St. Veit im Pongau, Austria.ORCID 0000-0003-1846-0331
Alain NickelsPediatric Rehabilitation Center Leuwaldhof, 5621 St. Veit im Pongau, Austria.
Maria RothmundUniversity Hospital of Psychiatry II, Department of Psychiatry, Psychotherapy, Psychosomatics and Medical Psychology, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-5299-9165
Gerhard RumpoldUniversity Hospital of Psychiatry II, Department of Psychiatry, Psychotherapy, Psychosomatics and Medical Psychology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Bernhard HolznerUniversity Hospital of Psychiatry I, Department of Psychiatry, Psychotherapy, Psychosomatics and Medical Psychology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Vincent GroteLudwig Boltzmann Institute for Rehabilitation Research, 1100 Vienna, Austria.ORCID 0000-0002-4421-2449
Michael J FischerLudwig Boltzmann Institute for Rehabilitation Research, 1100 Vienna, Austria.ORCID 0000-0002-6345-0813
Gustav FischmeisterPediatric Rehabilitation Center Leuwaldhof, 5621 St. Veit im Pongau, Austria.
Innsbruck Medical University · ATLudwig Boltzmann Institute for Cancer Research · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rehabilitation is a key element in improving health-related quality of life (HRQOL) for pediatric cancer survivors. The aim of this study was to present data from a multidisciplinary inpatient rehabilitation treatment. Children took part in a four-week multidisciplinary family-oriented inpatient rehabilitation. A total of 236 children (>5−21 years) and 478 parents routinely completed electronic patient-reported outcomes (ePROs), performance-based assessments, and clinician-rated assessments before (T1) and at the end (T2) of rehabilitation. HRQOL was assessed with the PedsQL generic core and PedsQL cancer module. Data were analyzed using repeated measures analysis of variance (ANOVA). Statistically significant improvements with medium to large effect sizes were observed for most HRQOL scales (η2 = 0.09−0.31), as well as performance-based and clinician-rated assessments for physical activity and functional status (η2 > 0.28). Agreement between children’s PROs and parents’ proxy ratings was lower before (rICC = 0.72) than after (rICC = 0.86) rehabilitation. While the concordance between children and parents’ assessment of changes during rehab was low to moderate (r = 0.19−0.59), the use of the performance score led to substantially increased scores (r = 0.29−0.68). The results of this naturalistic observational study thus highlight the benefits of multidisciplinary pediatric inpatient rehabilitation for childhood cancer survivors. The use of the performance score is recommended in this field.

Indexed as

HRQOLobservational studypediatric cancerpediatric rehabilitationperformance score

Identifiers

PMID36230777
PMCPMC9563065
OpenAlexW4303621970

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.