Evidence map›Paper›PMID 36230700›Full record

ReviewCancers2022

The Impact of Meat Intake on Bladder Cancer Incidence: Is It Really a Relevant Risk?

Achille Aveta, Crescenzo Cacciapuoti, Biagio Barone, Erika Di Zazzo, Francesco Del Giudice, Martina Maggi, Matteo Ferro, Daniela Terracciano, Gian Maria Busetto, Giuseppe Lucarelli and 14 more

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 3 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Bladder cancer risk factors: a comprehensive umbrella review of meta-analyses.International journal of surgery (London, England) · 2026
    Pooled it
  2. Pooled it
  3. Urinary MicroRNAs as Biomarkers of Urological Cancers: A Systematic Review.International journal of molecular sciences · 2023
    Pooled it
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Research progress on the microbiota in bladder cancer tumors.Frontiers in cellular and infection microbiology · 2024
    Review
  15. Article
  16. Article
  17. Article
  18. Impacts ofBiomedicines · 2023
    Article
  19. Article
  20. The Efficacy of FlogofilmJournal of clinical medicine · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 10 institutions in 3 countries.

Achille AvetaDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0001-8470-1995
Crescenzo CacciapuotiDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0001-6177-5545
Biagio BaroneDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0003-4884-132X
Erika Di ZazzoDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0001-7621-488X
Francesco Del GiudiceDepartment of Maternal Infant and Urologic Sciences, Policlinico Umberto I Hospital, "Sapienza" University of Rome, 00161 Rome, Italy.ORCID 0000-0003-3865-5988
Martina MaggiDepartment of Maternal Infant and Urologic Sciences, Policlinico Umberto I Hospital, "Sapienza" University of Rome, 00161 Rome, Italy.ORCID 0000-0003-4672-850X
Matteo FerroDivision of Urology, European Institute of Oncology IRCCS, 20141 Milan, Italy.ORCID 0000-0002-9250-7858
Daniela TerraccianoDepartment of Translational Medical Sciences, University of Naples "Federico II", 80131 Naples, Italy.ORCID 0000-0003-4296-429X
Gian Maria BusettoDepartment of Urology and Organ Transplantation, University of Foggia, 71122 Foggia, Italy.ORCID 0000-0002-7291-0316
Giuseppe LucarelliUrology, Andrology and Kidney Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy.ORCID 0000-0001-7807-1229
Octavian Sabin TataruThe Institution Organizing University Doctoral Studies (I.O.S.U.D.), George Emil Palade University of Medicine, Pharmacy, Sciences and Technology, 540142 Târgu Mureș, Romania.ORCID 0000-0001-7057-7815
Emanuele MontanariDepartment of Urology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via della Commenda 15, 20122 Milan, Italy.
Benito Fabio MirtoDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy.
Alfonso FalconeDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy.
Gaetano GiampagliaDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy.
Enrico SicignanoDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0003-2725-8530
Federico CaponeDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy.
Gianluca VillanoDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy.
Pasquale AngellottoDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy.
Celeste ManfrediUrology Unit, Department of Woman Child and of General and Specialist Surgery, University of Campania "Luigi Vanvitelli", 80121 Naples, Italy.ORCID 0000-0002-9706-8516
Luigi NapolitanoDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy.
Ciro ImbimboDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy.
Savio Domenico PandolfoDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0001-9621-3059
Felice CrocettoDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0002-4315-7660
University of Naples Federico II · ITPoliclinico Umberto I · ITChildren's Hospital of Richmond at VCU · USEuropean Institute of Oncology · ITUniversitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș · ROUniversity of Bari Aldo Moro · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Foggia · ITUniversity of Milan · ITUniversity of Molise · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bladder cancer (BC) represents the second most common genitourinary malignancy. The major risk factors for BC include age, gender, smoking, occupational exposure, and infections. The BC etiology and pathogenesis have not been fully defined yet. Since catabolites are excreted through the urinary tract, the diet may play a pivotal role in bladder carcinogenesis. Meat, conventionally classified as "red", "white" or "processed", represents a significant risk factor for chronic diseases like cardiovascular disease, obesity, type 2 diabetes, and cancer. In particular, red and processed meat consumption seems to increase the risk of BC onset. The most accepted mechanism proposed for explaining the correlation between meat intake and BC involves the generation of carcinogens, such as heterocyclic amines and polycyclic aromatic hydrocarbons by high-temperature cooking. This evidence claims the consumption limitation of meat. We reviewed the current literature on potential biological mechanisms underlying the impact of meat (red, white, and processed) intake on the increased risk of BC development and progression. Toward this purpose, we performed an online search on PubMed using the term "bladder cancer" in combination with "meat", "red meat", "white meat" or "processed meat". Although some studies did not report any association between BC and meat intake, several reports highlighted a positive correlation between red or processed meat intake, especially salami, pastrami, corned beef and bacon, and BC risk. We speculate that a reduction or rather a weighting of the consumption of red and processed meat can reduce the risk of developing BC. Obviously, this remark claims future indications regarding food education (type of meat to be preferred, quantity of red meat to be eaten and how to cook it) to reduce the risk of developing BC. Further well-designed prospective studies are needed to corroborate these findings.

Indexed as

bladder cancercarcinogenesisdietpreventionprocessed meatred meatwhite meat

Identifiers

PMID36230700
PMCPMC9564157
OpenAlexW4297982486

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.