Evidence map›Paper›PMID 36230644›Full record

ArticleCancers2022

Bis(chloroacetamidino)-Derived Heteroarene-Fused Anthraquinones Bind to and Cause Proteasomal Degradation of tNOX, Leading to c-Flip Downregulation and Apoptosis in Oral Cancer Cells.

Jeng Shiun Chang, Chien-Yu Chen, Alexander S Tikhomirov, Atikul Islam, Ru-Hao Liang, Chia-Wei Weng, Wei-Hou Wu, Andrey E Shchekotikhin, Pin Ju Chueh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Jeng Shiun ChangDepartment of Otolaryngology, Head and Neck Surgery, Jen-Ai Hospital, Taichung 41265, Taiwan.
Chien-Yu ChenInstitute of Biomedical Sciences, National Chung Hsing University, 145 Xingda Rd., Taichung 40227, Taiwan.ORCID 0000-0003-2445-6128
Alexander S TikhomirovGause Institute of New Antibiotics, 11 B. Pirogovskaya Street, 119021 Moscow, Russia.ORCID 0000-0002-6418-1539
Atikul IslamInstitute of Biomedical Sciences, National Chung Hsing University, 145 Xingda Rd., Taichung 40227, Taiwan.
Ru-Hao LiangInstitute of Biomedical Sciences, National Chung Hsing University, 145 Xingda Rd., Taichung 40227, Taiwan.
Chia-Wei WengInstitute of Biomedical Sciences, National Chung Hsing University, 145 Xingda Rd., Taichung 40227, Taiwan.ORCID 0000-0002-4842-7308
Wei-Hou WuInstitute of Biomedical Sciences, National Chung Hsing University, 145 Xingda Rd., Taichung 40227, Taiwan.
Andrey E ShchekotikhinGause Institute of New Antibiotics, 11 B. Pirogovskaya Street, 119021 Moscow, Russia.ORCID 0000-0002-6595-0811
Pin Ju ChuehInstitute of Biomedical Sciences, National Chung Hsing University, 145 Xingda Rd., Taichung 40227, Taiwan.ORCID 0000-0002-3200-7552
National Chung Hsing University · TWGause Institute of New Antibiotics Russian Academy of Medical Sciences · RUJen-Ai Hospital · TW

Funding

Jen-Ai Hospital C107-07Ministry of Sciences and Technology, Taiwan 108-2923-B-005-001-MY3the Russian Foundation for Basic Research 19-53-52008
6 · The paper itself

Abstract

Anthraquinone-based intercalating compounds, namely doxorubicin and mitoxantrone, have been used clinically based on their capacity to bind DNA and induce DNA damage. However, their applications have been limited by side effects and drug resistance. New-generation anthraquinone derivatives fused with different heterocycles have been chemically synthesized and screened for higher anticancer potency. Among the compounds reported in our previous study, 4,11-bis(2-(2-chloroacetamidine)ethylamino)anthra[2,3-b]thiophene-5,10-dione dihydrochloride (designated

Indexed as

anthraquinoneapoptosisc-Flip downregulationheterocyclic compoundsoral cancer cellstumor-associated NADH oxidase (tNOX, ENOX2)

Identifiers

PMID36230644
PMCPMC9562014
OpenAlexW4297464317

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.