Evidence map›Paper›PMID 36230631›Full record

ArticleCancers2022

Histone Deacetylase Inhibitors as a Therapeutic Strategy to Eliminate Neoplastic "Stromal" Cells from Giant Cell Tumors of Bone.

Sanne Venneker, Robin van Eenige, Alwine B Kruisselbrink, Ieva Palubeckaitė, Alice E Taliento, Inge H Briaire-de Bruijn, Pancras C W Hogendoorn, Michiel A J van de Sande, Hans Gelderblom, Hailiang Mei and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Denosumab Induces Neoplastic Stromal Cell ApoptosisCurrent cancer drug targets · 2024
    Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Sanne VennekerDepartment of Pathology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0002-4067-9818
Robin van EenigeDepartment of Cell and Chemical Biology, Leiden University Medical Center, 2333 ZC Leiden, The Netherlands.ORCID 0000-0003-2637-3801
Alwine B KruisselbrinkDepartment of Pathology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Ieva PalubeckaitėDepartment of Pathology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0002-2961-5469
Alice E TalientoDepartment of Pathology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0003-0900-9047
Inge H Briaire-de BruijnDepartment of Pathology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Pancras C W HogendoornDepartment of Pathology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0002-1513-8104
Michiel A J van de SandeDepartment of Orthopedic Surgery, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0002-9156-7656
Hans GelderblomDepartment of Medical Oncology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0001-9270-8636
Hailiang MeiSequencing Analysis Support Core (SASC), Leiden University Medical Center, 2333 ZC Leiden, The Netherlands.ORCID 0000-0003-1781-5508
Judith V M G BovéeDepartment of Pathology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0003-1155-0481
Karoly SzuhaiDepartment of Cell and Chemical Biology, Leiden University Medical Center, 2333 ZC Leiden, The Netherlands.ORCID 0000-0002-1228-4245
Leiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The neoplastic "stromal" cells in giant cell tumor of bone (GCTB) harbor a mutation in the

Indexed as

bone neoplasmepigeneticsgiant cell tumor of boneH3F3Ahistone deacetylasehistone H3.3 variantspanobinostatromidepsin

Identifiers

PMID36230631
PMCPMC9563449
OpenAlexW4297347985

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.