Evidence map›Paper›PMID 36230602›Full record

ArticleCancers2022

A New Survival Score for Patients ≥65 Years Assigned to Radiotherapy of Bone Metastases.

Dirk Rades, Cansu Delikanli, Steven E Schild, Charlotte Kristiansen, Søren Tvilsted, Stefan Janssen

Abstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dirk RadesDepartment of Radiation Oncology, University of Lubeck, 23562 Lubeck, Germany.
Cansu DelikanliDepartment of Radiation Oncology, University of Lubeck, 23562 Lubeck, Germany.
Steven E SchildDepartment of Radiation Oncology, Mayo Clinic, Scottsdale, AZ 85259, USA.
Charlotte KristiansenDepartment of Oncology, Vejle Hospital, University Hospital of Southern Denmark, 7100 Vejle, Denmark.ORCID 0000-0002-8073-5781
Søren TvilstedResearch Department, Zealand University Hospital, 4600 Køge, Denmark.
Stefan JanssenDepartment of Radiation Oncology, University of Lubeck, 23562 Lubeck, Germany.

Funding

European Regional Development Fund through the Interreg Deutschland-Danmark program 148-1.1-21
6 · The paper itself

Abstract

Survival scores are important for personalized treatment of bone metastases. Elderly patients are considered a separate group. Therefore, a specific score was developed for these patients. Elderly patients (≥65 years) irradiated for bone metastases were randomly assigned to the test (n = 174) or validation (n = 174) cohorts. Thirteen factors were retrospectively analyzed for survival. Factors showing significance (p < 0.05) or a trend (p < 0.06) in the multivariate analysis were used for the score. Based on 6-month survival rates, prognostic groups were formed. The score was compared to an existing tool developed in patients of any age. In the multivariate analysis, performance score, tumor type, and visceral metastases showed significance and gender was a trend. Three groups were designed (17, 18−25 and 27−28 points) with 6-month survival rates of 0%, 51%, and 100%. In the validation cohort, these rates were 9%, 55%, and 86%. Comparisons of prognostic groups between both cohorts did not reveal significant differences. In the test cohort, positive predictive values regarding death ≤6 and survival ≥6 months were 100% with the new score vs. 80% and 88% with the existing tool. The new score was more accurate demonstrating the importance of specific scores for elderly patients.

Indexed as

bone metastaseselderly patientsradiation therapysurvival scoretreatment personalization

Identifiers

PMID36230602
PMCPMC9563043

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.