Evidence map›Paper›PMID 36230593›Full record

ArticleCancers2022

The Development of a Prediction Model Based on Random Survival Forest for the Postoperative Prognosis of Pancreatic Cancer: A SEER-Based Study.

Jiaxi Lin, Minyue Yin, Lu Liu, Jingwen Gao, Chenyan Yu, Xiaolin Liu, Chunfang Xu, Jinzhou Zhu

Abstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiaxi LinDepartment of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou 215000, China.ORCID 0000-0003-4171-7457
Minyue YinDepartment of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou 215000, China.ORCID 0000-0002-3724-5744
Lu LiuDepartment of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou 215000, China.
Jingwen GaoDepartment of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou 215000, China.
Chenyan YuDepartment of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou 215000, China.
Xiaolin LiuDepartment of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou 215000, China.
Chunfang XuDepartment of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou 215000, China.
Jinzhou ZhuDepartment of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou 215000, China.ORCID 0000-0003-0544-9248

Funding

Science and Technology Plan of Suzhou City SKY2021038)Youth Program of Suzhou Health Committee KJXW2019001
6 · The paper itself

Abstract

Accurate prediction for the prognosis of patients with pancreatic cancer (PC) is a emerge task nowadays. We aimed to develop survival models for postoperative PC patients, based on a novel algorithm, random survival forest (RSF), traditional Cox regression and neural networks (Deepsurv), using the Surveillance, Epidemiology, and End Results Program (SEER) database. A total of 3988 patients were included in this study. Eight clinicopathological features were selected using least absolute shrinkage and selection operator (LASSO) regression analysis and were utilized to develop the RSF model. The model was evaluated based on three dimensions: discrimination, calibration, and clinical benefit. It found that the RSF model predicted the cancer-specific survival (CSS) of the postoperative PC patients with a c-index of 0.723, which was higher than the models built by Cox regression (0.670) and Deepsurv (0.700). The Brier scores at 1, 3, and 5 years (0.188, 0.177, and 0.131) of the RSF model demonstrated the model's favorable calibration and the decision curve analysis illustrated the model's value of clinical implement. Moreover, the roles of the key variables were visualized in the Shapley Additive Explanations plotting. Lastly, the prediction model demonstrates value in risk stratification and individual prognosis. In this study, a high-performance prediction model for PC postoperative prognosis was developed, based on RSF The model presented significant strengths in the risk stratification and individual prognosis prediction.

Indexed as

machine learningpancreatic cancerrandom survival forestsurgerythe Surveillance, Epidemiology, and End Results Program (SEER)visualization

Identifiers

PMID36230593
PMCPMC9563591

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.