Evidence map›Paper›PMID 36230506›Full record

ArticleCancers2022

LiMAx Prior to Radioembolization for Hepatocellular Carcinoma as an Additional Tool for Patient Selection in Patients with Liver Cirrhosis.

Catherine Leyh, Niklas Heucke, Clemens Schotten, Matthias Büchter, Lars P Bechmann, Marc Wichert, Alexander Dechêne, Ken Herrmann, Dominik Heider, Svenja Sydor and 17 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 7 institutions in 1 country.

Catherine LeyhDepartment of Gastroenterology, Hepatology and Transplant Medicine, University Hospital Essen, 45147 Essen, Germany.
Niklas HeuckeDepartment of Gastroenterology, Hepatology, and Infectious Diseases, Otto-von-Guericke University Magdeburg, 39120 Magdeburg, Germany.
Clemens SchottenDepartment of Gastroenterology, Hepatology and Transplant Medicine, University Hospital Essen, 45147 Essen, Germany.
Matthias BüchterDepartment of Gastroenterology, Hepatology and Transplant Medicine, University Hospital Essen, 45147 Essen, Germany.ORCID 0000-0003-3394-5492
Lars P BechmannDepartment of Internal Medicine, University Hospital Knappschaftskrankenhaus Bochum, Ruhr University Bochum, 44892 Bochum, Germany.
Marc WichertCentral Laboratory, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.
Alexander DechêneDepartment of Internal Medicine 6, Paracelsus Medical University Nürnberg, 90419 Nürnberg, Germany.
Ken HerrmannDepartment of Nuclear Medicine, University Hospital Essen, 45147 Essen, Germany.
Dominik HeiderDepartment of Mathematics and Computer Science, Philipps University of Marburg, 35032 Marburg, Germany.
Svenja SydorDepartment of Internal Medicine, University Hospital Knappschaftskrankenhaus Bochum, Ruhr University Bochum, 44892 Bochum, Germany.ORCID 0000-0002-1349-8309
Peter LemmerDepartment of Gastroenterology, Hepatology, and Infectious Diseases, Otto-von-Guericke University Magdeburg, 39120 Magdeburg, Germany.
Johannes M LudwigInstitute for Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, 45147 Essen, Germany.
Josef PospiechDepartment of Internal Medicine, University Hospital Knappschaftskrankenhaus Bochum, Ruhr University Bochum, 44892 Bochum, Germany.
Jens TheysohnInstitute for Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, 45147 Essen, Germany.ORCID 0000-0001-5869-7929
Robert DammDepartment of Radiology and Nuclear Medicine, Otto-von-Guericke University Magdeburg, 39120 Magdeburg, Germany.
Christine MarchDepartment of Radiology and Nuclear Medicine, Otto-von-Guericke University Magdeburg, 39120 Magdeburg, Germany.
Maciej PowerskiDepartment of Radiology and Nuclear Medicine, Otto-von-Guericke University Magdeburg, 39120 Magdeburg, Germany.
Maciej PechDepartment of Radiology and Nuclear Medicine, Otto-von-Guericke University Magdeburg, 39120 Magdeburg, Germany.ORCID 0000-0002-7140-6775
Mustafa ÖzcürümezDepartment of Internal Medicine, University Hospital Knappschaftskrankenhaus Bochum, Ruhr University Bochum, 44892 Bochum, Germany.
Jochen WeigtDepartment of Gastroenterology, Hepatology, and Infectious Diseases, Otto-von-Guericke University Magdeburg, 39120 Magdeburg, Germany.
Verena KeitelDepartment of Gastroenterology, Hepatology, and Infectious Diseases, Otto-von-Guericke University Magdeburg, 39120 Magdeburg, Germany.
Christian M LangeDepartment of Gastroenterology, Hepatology and Transplant Medicine, University Hospital Essen, 45147 Essen, Germany.
Hartmut SchmidtDepartment of Gastroenterology, Hepatology and Transplant Medicine, University Hospital Essen, 45147 Essen, Germany.ORCID 0000-0002-2402-7764
Ali CanbayDepartment of Internal Medicine, University Hospital Knappschaftskrankenhaus Bochum, Ruhr University Bochum, 44892 Bochum, Germany.ORCID 0000-0001-6069-7899
Jan BestDepartment of Gastroenterology, Hepatology, and Infectious Diseases, Otto-von-Guericke University Magdeburg, 39120 Magdeburg, Germany.
Guido GerkenDepartment of Gastroenterology, Hepatology and Transplant Medicine, University Hospital Essen, 45147 Essen, Germany.
Paul P MankaDepartment of Internal Medicine, University Hospital Knappschaftskrankenhaus Bochum, Ruhr University Bochum, 44892 Bochum, Germany.
Essen University Hospital · DEOtto-von-Guericke-Universität Magdeburg · DEUniversitätsklinikum Knappschaftskrankenhaus Bochum · DELMU Klinikum · DEParacelsus Medizinische Privatuniversität · DEPhilipps University of Marburg · DEUniversity of Duisburg-Essen · DE

Funding

Humedics (Germany) 108-21280
6 · The paper itself

Abstract

BACKGROUND AND

aimsRadioembolization (RE) has recently demonstrated a non-inferior survival outcome compared to systemic therapy for advanced hepatocellular carcinoma (HCC). Therefore, current guidelines recommend RE for patients with advanced HCC and preserved liver function who are unsuitable for transarterial chemoembolization (TACE) or systemic therapy. However, despite the excellent safety profile of RE, post-therapeutic hepatic decompensation remains a serious complication that is difficult to predicted by standard laboratory liver function parameters or imaging modalities. LiMAx PATIENTS AND

methodsIn total, 50 patients with HCC with or without liver cirrhosis and not amenable to TACE or systemic treatments were included in the study. For patients prospectively enrolled in our study, LiMAx

resultsWe observed a strong association between baseline LiMAx

conclusionPatients with lower LiMAx

Indexed as

enzymatic liver function testHCChepatocellular carcinomaLiMAx®radioembolizationselective internal radiotherapy

Identifiers

PMID36230506
PMCPMC9558955
OpenAlexW4296991021

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.