Evidence map›Paper›PMID 36230491›Full record

ArticleCancers2022

Effect of Pre-Existent Sarcopenia on Oncological Outcome of Advanced Thyroid Cancer Patients Treated with Tyrosine Kinase Inhibitors.

Cristina Dalmiglio, Lucia Brilli, Cristina Ciuoli, Fabio Maino, Laura Valerio, Ida Sannino, Alessandra Cartocci, Susanna Guerrini, Matteo Zanoni, Giuseppe Marrazzo and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Role of nutritional (PNI, CONUT) and inflammatory indices (SII) in predicting lymph node metastasis and prognosis of thyroid cancer: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Association between dietary zinc intake andFrontiers in nutrition · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Cristina DalmiglioUnit of Endocrinology, Department of Medical, Surgical and Neurological Sciences, University of Siena, 53100 Siena, Italy.
Lucia BrilliUnit of Endocrinology, Department of Medical, Surgical and Neurological Sciences, University of Siena, 53100 Siena, Italy.
Cristina CiuoliUnit of Endocrinology, Department of Medical, Surgical and Neurological Sciences, University of Siena, 53100 Siena, Italy.
Fabio MainoUnit of Endocrinology, Department of Medical, Surgical and Neurological Sciences, University of Siena, 53100 Siena, Italy.
Laura ValerioUnit of Endocrinology, Department of Medical, Surgical and Neurological Sciences, University of Siena, 53100 Siena, Italy.
Ida SanninoUnit of Endocrinology, Department of Medical, Surgical and Neurological Sciences, University of Siena, 53100 Siena, Italy.
Alessandra CartocciDepartment of Medical Biotechnologies, University of Siena, 53100 Siena, Italy.
Susanna GuerriniUnit of Diagnostic Imaging, Department of Medical, Surgical and Neuro Sciences and of Radiological Sciences, University of Siena, 53100 Siena, Italy.ORCID 0000-0001-7875-3342
Matteo ZanoniUnit of Diagnostic Imaging, Department of Medical, Surgical and Neuro Sciences and of Radiological Sciences, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-5847-3316
Giuseppe MarrazzoUnit of Diagnostic Imaging, Department of Medical, Surgical and Neuro Sciences and of Radiological Sciences, University of Siena, 53100 Siena, Italy.
Maria Antonietta MazzeiUnit of Diagnostic Imaging, Department of Medical, Surgical and Neuro Sciences and of Radiological Sciences, University of Siena, 53100 Siena, Italy.ORCID 0000-0001-6778-6894
Maria Grazia CastagnaUnit of Endocrinology, Department of Medical, Surgical and Neurological Sciences, University of Siena, 53100 Siena, Italy.
University of Siena · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: Sarcopenia is associated with poor survival and treatment outcomes in several human cancers. The aim of the study was to investigate the prevalence of sarcopenia in a cohort of 58 Caucasian patients with advanced thyroid cancer before and during TKI treatment. The impact of this condition on the outcome of patients was also evaluated. (2) Methods: Sarcopenia was evaluated using the Skeletal Muscle Index (SMI). (3) Results: Pre-treatment sarcopenia was found in 20.7% of patients and this condition significantly affected treatment outcome, emerging as the parameter that has the greatest impact on Progression Free Survival (PFS) (HR 4.29; 95% CI, 1.21−15.11, p = 0.02). A significant reduction in SMI values was observed 3 (p = 0.002) and 12 months (p < 0.0001) after TKI treatment. At a 12-month follow-up, sarcopenia prevalence increased up to 38.5%. Here, 12-month sarcopenia was predicted by a lower SMI (p = 0.029), BMI (p = 0.02) and weight (p = 0.04) and by the presence of bone metastases (p = 0.02). (4) Conclusions: This is the first study that evaluated sarcopenia prevalence and its change over time in Caucasian patients with advanced thyroid cancer under TKI therapy. Sarcopenia seems to be a prognostic factor of TKI treatment outcome, suggesting the importance of the assessment of the nutritional status and body composition in advanced thyroid cancer patients.

Indexed as

sarcopeniaSkeletal Muscle Indexthyroid cancertyrosine kinase inhibitors

Identifiers

PMID36230491
PMCPMC9559209
OpenAlexW4296897642

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.