Evidence map›Paper›PMID 36230457›Full record

ReviewAnimals : an open access journal from MDPI2022

Extracellular Vesicles in Veterinary Medicine.

Valentina Moccia, Alessandro Sammarco, Laura Cavicchioli, Massimo Castagnaro, Laura Bongiovanni, Valentina Zappulli

Open access · goldAbstract readReview
In one paragraph

Review in Animals : an open access journal from MDPI, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Beyond the Needle: Is Liquid Biopsy the Future of Veterinary Medicine?International journal of molecular sciences · 2026
    Review
  2. Extracellular Vesicles ofJournal of extracellular biology · 2026
    Article
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Valentina MocciaDepartment of Comparative Biomedicine and Food Science, University of Padova, 35020 Legnaro, Italy.ORCID 0000-0001-8843-0395
Alessandro SammarcoDepartment of Comparative Biomedicine and Food Science, University of Padova, 35020 Legnaro, Italy.ORCID 0000-0003-1977-3292
Laura CavicchioliDepartment of Comparative Biomedicine and Food Science, University of Padova, 35020 Legnaro, Italy.ORCID 0000-0002-2845-0244
Massimo CastagnaroDepartment of Comparative Biomedicine and Food Science, University of Padova, 35020 Legnaro, Italy.
Laura BongiovanniFaculty of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy.ORCID 0000-0001-8942-6048
Valentina ZappulliDepartment of Comparative Biomedicine and Food Science, University of Padova, 35020 Legnaro, Italy.ORCID 0000-0001-6203-0190
University of Padua · ITUniversity of Teramo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) are cell-derived membrane-bound vesicles involved in many physiological and pathological processes not only in humans but also in all the organisms of the eukaryotic and prokaryotic kingdoms. EV shedding constitutes a fundamental universal mechanism of intra-kingdom and inter-kingdom intercellular communication. A tremendous increase of interest in EVs has therefore grown in the last decades, mainly in humans, but progressively also in animals, parasites, and bacteria. With the present review, we aim to summarize the current status of the EV research on domestic and wild animals, analyzing the content of scientific literature, including approximately 220 papers published between 1984 and 2021. Critical aspects evidenced through the veterinarian EV literature are discussed. Then, specific subsections describe details regarding EVs in physiology and pathophysiology, as biomarkers, and in therapy and vaccines. Further, the wide area of research related to animal milk-derived EVs is also presented in brief. The numerous studies on EVs related to parasites and parasitic diseases are excluded, deserving further specific attention. The literature shows that EVs are becoming increasingly addressed in veterinary studies and standardization in protocols and procedures is mandatory, as in human research, to maximize the knowledge and the possibility to exploit these naturally produced nanoparticles.

Indexed as

biomarkerstherapyveterinary pathologyveterinary physiology

Identifiers

PMID36230457
PMCPMC9559303
OpenAlexW4303962073

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.