Value Ranges and Clinical Comparisons of Serum DHEA-S, IL-6, and TNF-α in Western Lowland Gorillas.

Ashley N Edes, Dawn Zimmerman, Balbine Jourdan, Janine L Brown, Katie L Edwards

Open access · goldAbstract read

In one paragraph

Article in Animals : an open access journal from MDPI, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.4field-weighted citation impact, top 25% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

Dehydroepiandrosterone (DHEA) as a tool for conservation.Environmental monitoring and assessment · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Ashley N EdesDepartment of Reproductive and Behavioral Sciences, Saint Louis Zoo, St. Louis, MO 63110, USA.ORCID 0000-0003-2127-1179

Dawn ZimmermanVeterinary Initiative for Endangered Wildlife, Bozeman, MT 59715, USA.

Balbine JourdanVeterinary Teaching Hospital, University of Illinois College of Veterinary Medicine, Urbana, IL 61802, USA.

Janine L BrownCenter for Species Survival, Smithsonian Conservation Biology Institute, Front Royal, VA 22630, USA.ORCID 0000-0003-3898-7755

Katie L EdwardsCenter for Species Survival, Smithsonian Conservation Biology Institute, Front Royal, VA 22630, USA.ORCID 0000-0001-6736-1183

Smithsonian Conservation Biology Institute · USSmithsonian Institution · USUniversity of Illinois Urbana-Champaign · US

Funding

Columbus Zoo and Aquarium n/aEndocrinology Research Laboratory at the Smithsonian Conservation Biology Institute n/aFriends of the National Zoo n/a

6 · The paper itself

Abstract

Physiological data can provide valuable information about the health and welfare of animals. Unfortunately, few validated assays and a lack of information on species-typical levels of circulating biomarkers for wildlife make the measurement, interpretation, and practical application of such data difficult. We validated commercially available kits and calculated reference intervals (herein called "value ranges") for dehydroepiandrosterone-sulfate (DHEA-S), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) in a sample of zoo-housed western lowland gorillas due to the roles these biomarkers play in stress and immune responses. For each biomarker, we present species-specific value ranges for a sample of gorillas in human care (

Indexed as

cytokineshealthHPA axisimmune responsereference intervalsstress responsezoo

Identifiers

PMID36230446

DOI10.3390/ani12192705

PMCPMC9559573

OpenAlexW4303685489

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.