Evidence map›Paper›PMID 36230267›Full record

ArticleAnimals : an open access journal from MDPI2022

Metabolomic Profiles in Starved Light Breed Horses during the Refeeding Process.

Sawyer C Main, Lindsay P Brown, Kelly R Melvin, Shawn R Campagna, Brynn H Voy, Hector F Castro, Lewrell G Strickland, Melissa T Hines, Robert D Jacobs, Mary E Gordon and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sawyer C MainDepartment of Animal Science, University of Tennessee, 2506 River Drive, Knoxville, TN 37996, USA.
Lindsay P BrownDepartment of Chemistry, University of Tennessee, 1420 Circle Drive, Knoxville, TN 37996, USA.ORCID 0000-0002-2496-3341
Kelly R MelvinDepartment of Animal Science, University of Tennessee, 2506 River Drive, Knoxville, TN 37996, USA.
Shawn R CampagnaDepartment of Chemistry, University of Tennessee, 1420 Circle Drive, Knoxville, TN 37996, USA.
Brynn H VoyDepartment of Animal Science, University of Tennessee, 2506 River Drive, Knoxville, TN 37996, USA.ORCID 0000-0003-1923-9110
Hector F CastroDepartment of Chemistry, University of Tennessee, 1420 Circle Drive, Knoxville, TN 37996, USA.
Lewrell G StricklandDepartment of Animal Science, University of Tennessee, 2506 River Drive, Knoxville, TN 37996, USA.
Melissa T HinesCollege of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA.
Robert D JacobsPurina Animal Nutrition, 100 Danforth Drive, Gray Summit, MO 63039, USA.
Mary E GordonPurina Animal Nutrition, 100 Danforth Drive, Gray Summit, MO 63039, USA.
Jennie L Z IveyDepartment of Animal Science, University of Tennessee, 2506 River Drive, Knoxville, TN 37996, USA.ORCID 0000-0002-8860-0080

Funding

Purina Animal Nutrition Independent contractStandlee Premium Western Forage Independent ContractUniversity of Tennessee at Knoxville One UT Collaboration and Innovation Grant
6 · The paper itself

Abstract

The large population of emaciated horses continues to be an issue troubling the equine industry. However, little is known regarding the collection of equine metabolites (metabolome) during a malnourished state and the changes that occur throughout nutritional rehabilitation. In this study, ten emaciated horses underwent a refeeding process, during which blood samples were collected for a blood chemistry panel and metabolomics analysis via ultrahigh performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS). Significant differences among blood chemistry analytes and metabolite abundance during the critical care period (CCP; Days 1-10 of rehabilitation) and the recovery period (RP; the remainder of the rehabilitation process) were observed. Potentially toxic compounds, analytes related to liver, kidney, and muscle function, as well as energy-related metabolites were altered during the refeeding process. The combination of blood chemistry and metabolomics analyses on starved equine during rehabilitation provide vital biological insight and evidence that the refeeding process has a significant impact on the equine metabolome.

Indexed as

body condition scoreemaciationequinehigh resolution mass spectrometrymalnourishedmetabolomicsrefeedingrehabilitation

Identifiers

PMID36230267
PMCPMC9559287

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.