ArticleCNS neuroscience & therapeutics2023
Altered dynamic functional network connectivity in levodopa-induced dyskinesia of Parkinson's disease.
Article in CNS neuroscience & therapeutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Functional motor network abnormalities associated with levodopa-induced dyskinesia in Parkinson's disease: A systematic review.NeuroImage. Clinical · 2024Pooled it
- Altered static and dynamic functional network connectivity in Parkinson's disease: A multisite functional magnetic resonance imaging study.IBRO neuroscience reports · 2026Article
- Altered Cortical Gyrification, Functional Connections, and Underlying Neurotransmitter Information in Patients with Parkinson's Disease with Levodopa-Induced Dyskinesia.Neurology and therapy · 2025Article
- Histamine Modulation of the Basal Ganglia Circuitry in the Motor Symptoms of Parkinson's Disease.CNS neuroscience & therapeutics · 2025Review
- Intrinsic brain functional connectivity predicts treatment-related motor complications in early Parkinson's disease patients.Journal of neurology · 2024Article
- Helicobacter pylori infection and Parkinson's Disease: etiology, pathogenesis and levodopa bioavailability.Immunity & ageing : I & A · 2024Review
- Convergent and divergent intra- and internetwork connectivity in Parkinson's disease with wearing-off.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Dynamic functional network connectivity in patients with a mismatch between white matter hyperintensity and cognitive function.Frontiers in aging neuroscience · 2024Article
- Voxel-based morphometry of grey matter structures in Parkinson's Disease with wearing-off.Brain imaging and behavior · 2023Article
- Altered dynamic functional network connectivity in drug-naïve Parkinson's disease patients with excessive daytime sleepiness.Frontiers in aging neuroscience · 2023Article
- Altered dynamic functional network connectivity in levodopa-induced dyskinesia of Parkinson's disease.CNS neuroscience & therapeutics · 2023Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe aim of this study was to clarify the dynamic neural activity of levodopa-induced dyskinesia (LID) in Parkinson's disease (PD).
methodsUsing dynamic functional network connectivity (dFNC) analysis, we evaluated 41 PD patients with LID (LID group) and 34 PD patients without LID (No-LID group). Group spatial independent component analysis and sliding-window approach were employed. Moreover, we applied a k-means clustering algorithm on windowed functional connectivity (FC) matrices to identify reoccurring FC patterns (i.e., states).
resultsThe optimal number of states was determined to be five, the so-called State 1, 2, 3, 4, and 5. In ON phase, compared with No-LID group, LID group occurred more frequently and dwelled longer in strongly connected State 1, characterized by strong positive connections between visual network (VIS) and sensorimotor network (SMN). When switching from OFF to ON phase, LID group occurred less frequently in State 3 and State 4. Meanwhile, LID group dwelled longer in State 2 and shorter in State 3. No-LID group occurred more frequently in State 5 and less frequently in State 3. Additionally, correlation analysis demonstrated that dyskinesia's severity was associated with frequency of occurrence and dwell time in State 2, dominated by inferior frontal cortex in cognitive executive network (CEN).
conclusionUsing dFNC analysis, we found that dyskinesia may be related to the dysfunctional inhibition of CEN on motor loops and excessive excitation of VIS and SMN, which provided evidence of the changes in brain dynamics associated with the occurrence of dyskinesia.
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