ArticleBMC neurology2022
Retinal microvasculature and cerebral hemodynamics in patients with internal carotid artery stenosis.
Article in BMC neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Changes in the retina and choroid in patients with internal carotid artery stenosis: a systematic review and meta-analysis.Frontiers in neuroscience · 2024Pooled it
- Associations between carotid macrovascular and retinal microvascular alterations in diabetes: Evidence synthesis and implications for risk assessment.Atherosclerosis plus · 2026Review
- Review
- Review
- Associations Between Retinal Microvasculature, Orbital Blood Flow, and Cerebral Blood Flow in Healthy Adults.Investigative ophthalmology & visual science · 2025Article
- Optical coherence tomography angiography in patients with focal epilepsy.Frontiers in neurology · 2025Article
- Detection of macular and peripheral ocular microvascular changes after carotid artery revascularization using widefield SS-OCTA.Frontiers in medicine · 2025Article
- Influence of Carotid Artery Stenting on the Retina and Choroid.Translational vision science & technology · 2024Article
- Choriocapillaris reduction accurately discriminates against early-onset Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Insight into the Brain: Application of the Retinal Microvasculature as a Biomarker for Cerebrovascular Diseases through Optical Coherence Tomography Angiography.Current ophthalmology reports · 2024Article
- Hemodynamic study of blood flow in the aorta during the interventional robot treatment using fluid-structure interaction.Biomechanics and modeling in mechanobiology · 2023Article
- Retinal Microvascular Changes in Internal Carotid Artery Stenosis.Journal of clinical medicine · 2023Article
- Length of Carotid Plaque Impacts Retinal Microvascular Densities of Carotid Artery Stenosis Patients.Translational vision science & technology · 2023Article
- Differential reductions in the capillary red-blood-cell flux between retina and brain under chronic global hypoperfusion.Neurophotonics · 2023Article
- Decreased Choriocapillaris Vessel Density in the Ipsilateral Eye after Carotid Artery Revascularization Detected by Widefield Swept-Source OCT Angiography.Ophthalmology scienceArticle
- Optical coherence tomography angiography to assess for retinal vascular changes in Neuro-Sjögren.Therapeutic advances in ophthalmologyArticle
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the relationship between retinal microvasculature and cerebral hemodynamics in patients with internal carotid artery (ICA) stenosis.
methodsPatients with unilateral moderate or severe ICA stenosis(≥50%) from West China hospital, Sichuan university were consecutively and prospectively recruited enrolled in the current study. En face angiograms of the superficial vascular complex (SVC), deep vascular complex (DVC), superficial vascular plexus (SVP), intermediate capillary plexus (ICP), and deep capillary plexus (DCP) were generated by automatic segmentation using swept-source optical coherence tomography angiography (SS-OCTA) to assess the retinal microvascular perfusion. The cerebral blood flow perfusion on bilateral middle cerebral artery territories measured at the basal ganglia level was assessed by brain computed tomography perfusion (CTP). CTP data were postprocessed to generate maps of different perfusion parameters including cerebral blood flow (CBF), cerebral blood volume (CBV), time to peak (TTP), mean transit time (MTT) and permeability surface(PS). Relative perfusion parameters (rPS, rCBF, etc.) were calculated as the ratio of the value on the contralateral side to that on the ipsilateral side.
resultsIn the final analysis, 31 patients were included, of whom 11 patients had a moderate ICA stenosis (50-69%) and 20 with a severe ICA stenosis(≥70%). A total of 55 eyes were analyzed in the study, 27 eyes from the ipsilateral side (ie, side with stenosis) and 28 eyes from the contralateral side. In the patients with ICA stenosis, there was a strong correlation between the retinal microvascular perfusion of SVC with rCBV(B = 0.45, p = 0.03), rCBF(B = 0.26, p = 0.02) and rPS(B = 0.45, p < 0.001) after adjustment for age, sex and vascular risk factors. Similar correlations were also found between microvasculature in SVP and cerebral perfusion changes. There were no any significant associations of microvascular perfusion in both DVC and DCP with CTP parameters(all p > 0.05).
conclusionsRetinal perfusion changes in superficial vascular layer (SVC and SVP) were correlated with brain hemodynamic compromise in patients with unilateral moderate or severe ICA stenosis(≥50%). Given the limited size of our study, future studies with larger sample size are needed to confirm our findings.
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