ArticleGeroScience2023
Topographical differences in white matter hyperintensity burden and cognition in aging, MCI, and AD.
Article in GeroScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Arterial Spin Labeling Hemodynamic Indices Relate to Cognitive and Small Vessel Disease Trajectories Over 11 Years.Stroke · 2026Article
- Norms for Automatic Estimation of White Matter Hyperintensities Burden: LST-AI Service in neuGRID.Diagnostics (Basel, Switzerland) · 2026Article
- EENet-RLA: An Explainable Prediction Learning Framework for Alzheimer's Disease Classification from EEG Signals.Brain topography · 2026Article
- Age-inappropriate white matter injury reveals hidden cerebral small vessel disease burden and mortality risk.Cerebral circulation - cognition and behavior · 2026Article
- Amyloid and tau pathologies are drivers of white matter damage in aging and Alzheimer's disease.medRxiv : the preprint server for health sciences · 2025Article
- Article
- Racial and ethnic differences in white matter hypointensities: The role of vascular risk factors.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Structural and microstructural changes in white and gray matter across the Alzheimer's disease continuum.Frontiers in aging neuroscience · 2025Review
- Apathy progression is associated with brain atrophy and white matter damage in Parkinson's disease.Brain communications · 2025Article
- Beyond Hypertension: Examining Variable Blood Pressure's Role in Cognition and Brain Structure.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024Article
- From Gut Microbiota to Brain Waves: The Potential of the Microbiome and EEG as Biomarkers for Cognitive Impairment.International journal of molecular sciences · 2024Review
- Beyond Hypertension: Examining Variable Blood Pressure's Role in Cognition and Brain Structure.medRxiv : the preprint server for health sciences · 2024Article
- The Alzheimer's Disease Neuroimaging Initiative in the era of Alzheimer's disease treatment: A review of ADNI studies from 2021 to 2022.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Review
- Sex differences in risk factors, burden, and outcomes of cerebrovascular disease in Alzheimer's disease populations.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- White Matter Hyperintensity Trajectories in Patients With Progressive and Stable Mild Cognitive Impairment.Neurology · 2023Article
- White matter hyperintensity load varies depending on subjective cognitive decline criteria.GeroScience · 2023Article
- The fibroblast growth factor system in cognitive disorders and dementia.Frontiers in neuroscience · 2023Review
- Intersecting vulnerabilities: race, depression, and white matter hypointensity burden in aging.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Investigating the relationship between sleep disturbances and white matter hyperintensities in older adults on the Alzheimer's disease spectrum.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Neighborhood greenspace and neighborhood income associated with white matter grade worsening: Cardiovascular Health Study.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
White matter hyperintensities (WMHs) are pathological changes that occur with increased age and are associated with cognitive decline. Most WMH research has not examined regional differences and focuses on a whole-brain approach. This study examined regional WMHs between normal controls (NCs), people with mild cognitive impairment (MCI), and Alzheimer's disease (AD). We also examined whether WMHs were associated with cognitive decline. Participants from the Alzheimer's Disease Neuroimaging Initiative were included if they had at least one WMH measurement and cognitive scores examining global cognition, executive functioning, and memory. Only amyloid-positive MCI and AD participants were included. A total of 1573 participants with 7381 timepoints over a maximum period of 13 years were included. Linear mixed-effects models examined group differences in WMH burden and associations between WMH burden and cognition. People with MCI and AD had increased total and regional WMHs compared to NCs. An association between WMHs and cognition was observed for global cognition, executive functioning, and memory in NCs in all regions. A steeper decline (stronger association between WMH and cognition) was observed in MCI compared to NCs for all cognitive domains in all regions. A steeper decline was observed in AD compared to NCs for global cognition in only the temporal region. A strong association is observed between all cognitive domains of interest and WMH burden in healthy aging and MCI, while those with AD only had a few associations between WMH and global cognition. These findings suggest that the WMH burden is associated with changes in cognition in healthy aging and early cognitive decline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.