ArticleBiomechanics and modeling in mechanobiology2022
Multi-level personalization of neuromusculoskeletal models to estimate physiologically plausible knee joint contact forces in children.
Article in Biomechanics and modeling in mechanobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Perspective: One and one make three - leveraging the synergy of imaging and biomechanics in osteoarthritis research and care.Osteoarthritis imaging · 2026Article
- A Musculoskeletal-Finite Element Study of Knee Joint Loading and Cartilage Mechanics in Children with Cerebral Palsy.Annals of biomedical engineering · 2026Article
- Ontogenetic changes in femoral morphology and joint loads in children.Bone & joint research · 2026Article
- Exploring the effect of different neural strategies on the knee joint contact forces during walking in adults.Scientific reports · 2026Article
- Do we need medical imaging-informed musculoskeletal models for simulations in healthy adults? A new workflow based on magnetic resonance imaging highlights the importance of personalized geometry.PLoS computational biology · 2026Article
- A forward dynamics framework for parameter optimization of the EMG-driven musculoskeletal model.Journal of neuroengineering and rehabilitation · 2026Article
- Advanced Biomaterial-Based In Vitro Osteoarthritis Models: Integrating Sex as a Biological Variable in Hormonal, Subchondral Bone, and Mechanobiological Pathways.Journal of functional biomaterials · 2026Review
- Evidence-informed methodological approaches for coupled neuromusculoskeletal-finite element analysis workflows in orthopaedic biomechanics.Frontiers in bioengineering and biotechnology · 2026Article
- Ankle Exoskeleton Assistance Reduces Knee Contact Force During Walking in Individuals With Cerebral Palsy.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026Article
- Benchmarking Neural Network Personalized Musculoskeletal Hand Models Against Current Personalization Standards Using Experimental Magnetic Resonance Imaging and Fine-Wire Electromyography.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026Article
- Functional symmetrization of neuromotor modules during locomotor development in human infants.Communications biology · 2025Article
- EMG-Informed Neuromusculoskeletal Simulations Increase the Accuracy of the Estimation of Knee Joint Contact Forces During Sub-optimal Level Walking.Annals of biomedical engineering · 2025Article
- Article
- Comparison of synergy extrapolation and static optimization for estimating multiple unmeasured muscle activations during walking.Journal of neuroengineering and rehabilitation · 2024Article
- Evaluation of 3D Footprint Morphology of Knee-Related Muscle Attachments Based on CT Data Reconstruction: A Feasibility Study.Life (Basel, Switzerland) · 2024Article
- A framework based on subject-specific musculoskeletal models and Monte Carlo simulations to personalize muscle coordination retraining.Scientific reports · 2024Article
- Musculoskeletal spine modeling in large patient cohorts: how morphological individualization affects lumbar load estimation.Frontiers in bioengineering and biotechnology · 2024Article
- Towards a comprehensive biomechanical assessment of the elderly combiningFrontiers in bioengineering and biotechnology · 2024Article
- Limiting the Use of Electromyography and Ground Reaction Force Data Changes the Magnitude and Ranking of Modelled Anterior Cruciate Ligament Forces.Bioengineering (Basel, Switzerland) · 2023Article
- Computational prediction of muscle synergy using a finite element framework for a musculoskeletal model on lower limb.Frontiers in bioengineering and biotechnology · 2023Article
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6 authors.
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Abstract
Neuromusculoskeletal models are a powerful tool to investigate the internal biomechanics of an individual. However, commonly used neuromusculoskeletal models are generated via linear scaling of generic templates derived from elderly adult anatomies and poorly represent a child, let alone children with a neuromuscular disorder whose musculoskeletal structures and muscle activation patterns are profoundly altered. Model personalization can capture abnormalities and appropriately describe the underlying (altered) biomechanics of an individual. In this work, we explored the effect of six different levels of neuromusculoskeletal model personalization on estimates of muscle forces and knee joint contact forces to tease out the importance of model personalization for normal and abnormal musculoskeletal structures and muscle activation patterns. For six children, with and without cerebral palsy, generic scaled models were developed and progressively personalized by (1) tuning and calibrating musculotendon units' parameters, (2) implementing an electromyogram-assisted approach to synthesize muscle activations, and (3) replacing generic anatomies with image-based bony geometries, and physiologically and physically plausible muscle kinematics. Biomechanical simulations of gait were performed in the OpenSim and CEINMS software on ten overground walking trials per participant. A mixed-ANOVA test, with Bonferroni corrections, was conducted to compare all models' estimates. The model with the highest level of personalization produced the most physiologically plausible estimates. Model personalization is crucial to produce physiologically plausible estimates of internal biomechanical quantities. In particular, personalization of musculoskeletal anatomy and muscle activation patterns had the largest effect overall. Increased research efforts are needed to ease the creation of personalized neuromusculoskeletal models.
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