ArticleBiomechanics and modeling in mechanobiology2023
Sensitivity of a two-dimensional biomorphoelastic model for post-burn contraction.
Article in Biomechanics and modeling in mechanobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Biomorphoelasticity alone: limitations in modeling post-burn contraction and hypertrophy without finite strains.Biomechanics and modeling in mechanobiology · 2025Article
- SVF-gel application for the alleviation of full-thickness skin graft contraction: an experimental study in mice.Scientific reports · 2025Article
- The Course of Scar Formation and Predictors of Scar Quality in 490 Paediatric Burn Patients During the First Year Post-Burn.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyArticle
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Authors and funding
4 authors.
Funding
Abstract
We consider a two-dimensional biomorphoelastic model describing post-burn scar contraction. This model describes skin displacement and the development of the effective Eulerian strain in the tissue. Besides these mechanical components, signaling molecules, fibroblasts, myofibroblasts, and collagen also play a significant role in the model. We perform a sensitivity analysis for the independent parameters of the model and focus on the effects on features of the relative surface area and the total strain energy density. We conclude that the most sensitive parameters are the Poisson's ratio, the equilibrium collagen concentration, the contraction inhibitor constant, and the myofibroblast apoptosis rate. Next to these insights, we perform a sensitivity analysis where the proliferation rates of fibroblasts and myofibroblasts are not the same. The impact of this model adaptation is significant.
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