Evidence map›Paper›PMID 36229649›Full record

ArticleThe pharmacogenomics journal2023

Protein network and pathway analysis in a pharmacogenetic study of cyclosporine treatment response in Greek patients with psoriasis.

Charalabos Antonatos, Aikaterini Patsatsi, Efterpi Zafiriou, Eleana F Stavrou, Andreas Liaropoulos, Aikaterini Kyriakoy, Evangelos Evangelou, Danai Digka, Angeliki Roussaki-Schulze, Dimitris Sotiriadis and 4 more

Abstract read
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In one paragraph

Article in The pharmacogenomics journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Single-CellInternational journal of molecular sciences · 2026
    Article
  4. Review
  5. Review
  6. Pharmaco-Omics in Psoriasis: Paving the Way towards Personalized Medicine.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Charalabos AntonatosLaboratory of Genetics, Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, Patras, Greece.ORCID 0000-0002-5967-9367
Aikaterini Patsatsi2nd Dermatology Department, Medical School, Papageorgiou Hospital, Aristotle University, Thessaloniki, Greece.
Efterpi ZafiriouDepartment of Dermatology, University General Hospital Larissa, University of Thessaly, Volos, Greece.
Eleana F StavrouLaboratory of Genetics, Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, Patras, Greece.
Andreas LiaropoulosLaboratory of Genetics, Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, Patras, Greece.ORCID 0000-0002-0764-2933
Aikaterini Kyriakoy2nd Dermatology Department, Medical School, Papageorgiou Hospital, Aristotle University, Thessaloniki, Greece.
Evangelos EvangelouDepartment of Hygiene and Epidemiology, Medical School, University of Ioannina, Ioannina, Greece.
Danai DigkaLaboratory of Genetics, Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, Patras, Greece.
Angeliki Roussaki-SchulzeDepartment of Dermatology, University General Hospital Larissa, University of Thessaly, Volos, Greece.
Dimitris Sotiriadis2nd Dermatology Department, Medical School, Papageorgiou Hospital, Aristotle University, Thessaloniki, Greece.
Sophia GeorgiouDermatology Department, Medical School, University of Patras, Patras, Greece.
Katerina GrafanakiDermatology Department, Medical School, University of Patras, Patras, Greece.ORCID 0000-0002-6569-1928
Nicholas Κ MoschonasLab. of General Biology, Medical School, University of Patras, Patras, Greece.ORCID 0000-0002-2556-537X
Yiannis VasilopoulosLaboratory of Genetics, Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, Patras, Greece. iovasilop@upatras.gr.ORCID 0000-0002-3167-7642
University of Patras · GRPapageorgiou General Hospital · GRUniversity of Thessaly · GRComputer Technology Institute and Press “DIOPHANTUS” · GRUniversity of Ioannina · GR

Funding

Medical Research Council MR/S019669/1
6 · The paper itself

Abstract

Although cyclosporine comprises a well-established systemic therapy for psoriasis, patients show important heterogeneity in their treatment response. The aim of our study was the pharmacogenetic analysis of 200 Greek patients with psoriasis based on the cyclosporine pathway related protein-protein interaction (PPI) network, reconstructed through the PICKLE meta-database. We genotyped 27 single nucleotide polymorphisms, mapped to 22 key protein nodes of the cyclosporine pathway, via the utilization of the iPLEX®GOLD panel of the MassARRAY® System. Single-SNP analyses showed statistically significant associations between CALM1 rs12885713 (P = 0.0108) and MALT1 rs2874116 (P = 0.0006) polymorphisms with positive response to cyclosporine therapy after correction for multiple comparisons, with the haplotype analyses further enhancing the predictive value of rs12885713 as a pharmacogenetic biomarker for cyclosporine therapy (P = 0.0173). Our findings have the potential to improve our prediction of cyclosporine efficacy and safety in psoriasis patients, as well as provide the framework for the pharmacogenetics of biological therapies in complex diseases.

Indexed as

CyclosporinePsoriasisGreeceHumansPharmacogeneticsPharmacogenomic TestingCyclosporine

Identifiers

PMID36229649
OpenAlexW4305014090

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.