Evidence map›Paper›PMID 36229634›Full record

ArticleScientific reports2022

Blood pressure variability and plasma Alzheimer's disease biomarkers in older adults.

Isabel J Sible, Belinda Yew, Jung Yun Jang, John Paul M Alitin, Yanrong Li, Aimée Gaubert, Amy Nguyen, Shubir Dutt, Anna E Blanken, Jean K Ho and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Frontiers in aging neuroscience · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Genome-wide pleiotropy analysis of longitudinal blood pressure and harmonized cognitive performance measures.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  11. Blood pressure variability: a review.Journal of hypertension · 2025
    Review
  12. Article
  13. Observational
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Isabel J SibleDepartment of Psychology, University of Southern California, Los Angeles, CA, 90089, USA.
Belinda YewDepartment of Psychology, University of Southern California, Los Angeles, CA, 90089, USA.
Jung Yun JangInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, 4201 Social and Behavioral Sciences Gateway, Irvine, CA, 92697-7085, USA.
John Paul M AlitinInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, 4201 Social and Behavioral Sciences Gateway, Irvine, CA, 92697-7085, USA.
Yanrong LiInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, 4201 Social and Behavioral Sciences Gateway, Irvine, CA, 92697-7085, USA.
Aimée GaubertInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, 4201 Social and Behavioral Sciences Gateway, Irvine, CA, 92697-7085, USA.
Amy NguyenInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, 4201 Social and Behavioral Sciences Gateway, Irvine, CA, 92697-7085, USA.
Shubir DuttDepartment of Psychology, University of Southern California, Los Angeles, CA, 90089, USA.
Anna E BlankenSan Francisco Veterans Affairs Health Care System, San Francisco, CA, 94121, USA.
Jean K HoInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, 4201 Social and Behavioral Sciences Gateway, Irvine, CA, 92697-7085, USA.
Anisa J MarshallDepartment of Psychology, University of Southern California, Los Angeles, CA, 90089, USA.
Arunima KapoorDepartment of Psychological Science, University of California, Irvine, Irvine, CA, 92697, USA.
Fatemah ShenasaDepartment of Psychological Science, University of California, Irvine, Irvine, CA, 92697, USA.
Kathleen E RodgersDepartment of Pharmacology, Center for Innovation in Brain Science, The University of Arizona, Tucson, AZ, 85721, USA.
Virginia E SturmDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA, 94158, USA.
Elizabeth HeadDepartment of Pathology & Laboratory Medicine, University of California, Irvine, Irvine, CA, 92697, USA.
Alessandra MartiniDepartment of Pathology & Laboratory Medicine, University of California, Irvine, Irvine, CA, 92697, USA.
Daniel A NationInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, 4201 Social and Behavioral Sciences Gateway, Irvine, CA, 92697-7085, USA. dnation@uci.edu.

Funding

Vascular Contributions to Dementia and Genetic Risk Factors for Alzheimer's DiseaseP01AG052350 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation, ARTHUR W TOGA · 2016 to 2026
$28.4M
The Alzheimer's Disease Research Center at the University of California, IrvineP30AG066519 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Mathew Mark Blurton-Jones · 2020 to 2026
$27.9M
Endothelial progenitor cells and neurovascular injury in the aging brainR01AG064228 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation · 2019 to 2026
$4.5M
Emotion alterations across the Alzheimer's disease spectrumR01AG073244 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STURM, VIRGINIA EMILY · 2021 to 2025
$4.0M
Neurobiological Basis of Emotion Regulation Trajectories in Early Alzheimer's DiseaseR01AG057204 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STURM, VIRGINIA EMILY · 2017 to 2021
$3.9M
Cerebrovascular resistance in cognitive aging and Alzheimer's disease riskR01AG060049 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI NATION, DANIEL A · 2020 to 2023
$2.4M
NIA NIH HHS P01 AG052350NIA NIH HHS P30 AG066519NIA NIH HHS R01 AG057204NIA NIH HHS R01 AG060049NIA NIH HHS R01 AG064228NIA NIH HHS R01 AG073244
6 · The paper itself

Abstract

Blood pressure variability is an emerging risk factor for Alzheimer's disease in older adults, independent of average blood pressure levels. Growing evidence suggests increased blood pressure variability is linked to Alzheimer's disease pathophysiology indexed by cerebrospinal fluid and positron emission tomography markers, but relationships with plasma Alzheimer's disease markers have not been investigated. In this cross-sectional study of 54 community-dwelling older adults (aged 55-88, mean age 69.9 [8.2 SD]), elevated blood pressure variability over 5 min was associated with lower levels of plasma Aβ

Indexed as

Alzheimer DiseaseAgedAged, 80 and overAmyloid beta-PeptidesBiomarkersBlood PressureCross-Sectional StudiesHumansMiddle AgedPeptide Fragmentstau ProteinsTomography, X-Ray ComputedAmyloid beta-PeptidesBiomarkersPeptide Fragmentstau Proteins

Identifiers

PMID36229634
PMCPMC9561652

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.