ArticleNature communications2022
[2]-Ladderanes as isosteres for meta-substituted aromatic rings and rigidified cyclohexanes.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Programmable regiodivergent light-driven cyclization of acyclic 1,5-dienes unlocks rigid bicyclic architectures.Nature chemistry · 2026Article
- Concise synthesis and strain-release diversification of bridgehead-substituted [2]-ladderanes.Nature chemistry · 2026Article
- Ladder-shaped molecules for the masses.Nature chemistry · 2026Article
- Atomic degradation: chemical design strategies and immunotherapeutic mechanisms of radio-PROTACs.Annals of nuclear medicine · 2026Review
- Collective synthesis of 1,2,4-trisubstituted, meta- and ortho-substituted arene bioisosteres from bicyclobutanes.Nature chemistry · 2026Article
- Boron-Enabled Stereoselective Synthesis of Polysubstituted Housanes.Journal of the American Chemical Society · 2025Article
- Polycyclic Scaffolds through the Intermediacy of Boron-Stabilized Nonclassical Carbocations.Journal of the American Chemical Society · 2025Article
- Challenges of Aufheben to Promote Druglikeness: Chemical Modification Strategies to Improve Aqueous Solubility and Permeability.Journal of medicinal chemistry · 2025Review
- Pathway-divergent coupling of alkynes and cyclobutenes through enantioselective cobalt catalysis.Nature communications · 2025Article
- Enantioselective photocatalytic synthesis of bicyclo[2.1.1]hexanes as ortho-disubstituted benzene bioisosteres with improved biological activity.Nature chemistry · 2025Article
- Facile Synthesis of Housanes by an Unexpected Strategy.Journal of the American Chemical Society · 2025Article
- Expanding the Repertoire of Large Scaffolds withThe Journal of organic chemistry · 2025Article
- Enantioselective [2π + 2σ] Photocycloaddition Enabled by Brønsted Acid Catalyzed Chromophore Activation.Journal of the American Chemical Society · 2024Article
- Article
- Three-dimensional saturated C(spNature reviews. Chemistry · 2024Review
- Template-Directed Selective Photodimerization Reactions of 5-Arylpenta-2,4-dienoic Acids.The Journal of organic chemistry · 2024Article
- Synthetic techniques for thermodynamically disfavoured substituted six-membered rings.Nature reviews. Chemistry · 2024Review
- Analogies between photochemical reactions and ground-state post-transition-state bifurcations shed light on dynamical origins of selectivity.Nature chemistry · 2024Article
- (Bio)isosteres ofBeilstein journal of organic chemistry · 2024Review
- Synthesis of 2-Azanorbornanes via Strain-Release Formal Cycloadditions Initiated by Energy Transfer.Angewandte Chemie (International ed. in English) · 2023Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Aromatic ring isosteres and rigidified saturated hydrocarbons are important motifs to enable drug discovery. Herein we disclose [2]-ladderanes as a class of meta-substituted aromatic ring isosteres and rigidified cyclohexanes. A straightforward synthesis of the building blocks is presented along with representative derivatization. Preliminary studies reveal that the [2]-ladderanes offer similar metabolic and physicochemical properties thus establishing this class of molecules as interesting motifs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.