Evidence map›Paper›PMID 36229561›Full record

ArticleInternational ophthalmology2023

Canaloplasty and trabeculotomy with the OMNI

Daniel C Terveen, Steven R Sarkisian, Steven D Vold, Deepan Selvadurai, Blake K Williamson, Deborah G Ristvedt, Adam R Bleeker, Kavita Dhamdhere, Jaime E Dickerson

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Ab Interno Goniotomy/Goniectomy TechniquesTurkish journal of ophthalmology · 2025
    Review
  3. Visual Function After Schlemm's Canal-Based MIGS.Journal of clinical medicine · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Alternatives to Topical Glaucoma Medication for Glaucoma Management.Clinical ophthalmology (Auckland, N.Z.) · 2023
    Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Daniel C TerveenVance Thompson Vision, Sioux Falls, SD, USA.
Steven R SarkisianOklahoma Eye Surgeons, PLLC., Oklahoma City, OK, USA.
Steven D VoldVold Vision, Fayetteville, AR, USA.
Deepan SelvaduraiBuffalo Ophthalmology, Williamsville, NY, USA.
Blake K WilliamsonThe Williamson Eye Center., Baton Rouge, LA, USA.
Deborah G RistvedtVance Thompson Vision, Alexandria, MN, USA.
Adam R BleekerVance Thompson Vision, Sioux Falls, SD, USA.
Kavita DhamdhereSight Sciences, Inc., Menlo Park, CA, USA.
Jaime E DickersonSight Sciences, Inc., Menlo Park, CA, USA. jaime.dickerson@unthsc.edu.
Vance Thompson Vision · USGandhi Medical College · INMenlo School · USNorthwest Eye Surgeons · USUniversity of South Dakota · USWilliams (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeEvaluate effectiveness and safety outcomes for patients treated with canaloplasty and trabeculotomy previously treated with a trabecular microbypass stent (TBS).

methodsRetrospective, multicenter, IRB approved study. Patients treated with TBS (iStent/iStent inject, Glaukos) and subsequently with OMNI surgical system (OSS) (Sight Sciences). From 5 practices in 5 US states. Open-angle glaucoma (OAG), minimum 3 months follow-up after OSS surgery, Pre-OSS IOP ≥ 17 mmHg on ≥ 1 medication. No glaucoma procedures between TBS and OSS. ENDPOINTS: proportion with ≥ 20% reduction in IOP, IOP between 6 and 18 mmHg, mean IOP, change in IOP, mean number of medications. Adverse events and secondary surgical interventions (SSI). Mann-Whitney rank sum test compared pre-OSS IOP and medications with follow-up.

resultsTwenty seven patients. Average age (SD) 72.2 (10.8), 22/27 primary OAG (82%), mean MD - 6.2 (7.0) dB. Mean IOP before OSS 22.3 (4.3) mmHg on 2.2 (1.3) medications. At last follow-up (mean 11 months) IOP was 17.2 mmHg on 1.8 medications, - 5.1 mmHg (- 23%, p < .001), - 0.4 meds (- 18%, p = .193); ≥ 20% IOP reduction (41%), IOP ≤ 18 (56%). Adverse events were non-serious. Hyphema > 1 mm (3, 11%), BCVA decrease (4, 15%), IOP spike (2, 7%). SSI (4, 15%) had higher pre-OSS IOP (23.4 mmHg) and worse MD (- 9.6 dB).

conclusionPatients uncontrolled by medication and a prior TBS would once have been candidates for trabeculectomy and tube shunts. OSS offered a minimally invasive option that provided IOP control and avoidance of traditional surgery for the majority over follow-up averaging 11 months and up to 42 months.

Indexed as

Glaucoma, Open-AngleTrabeculectomyHumansIntraocular PressureRetrospective StudiesStentsTreatment OutcomeiStentMIGSOMNI surgical systemOpen-angle glaucomaTrabeculotomyViscodilation

Identifiers

PMID36229561
PMCPMC10149460
OpenAlexW4305014052

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.