ArticleHypertension research : official journal of the Japanese Society of Hypertension2023
Contributions of renal water loss and skin water conservation to blood pressure elevation in spontaneously hypertensive rats.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Transepidermal water loss is positively correlated with blood pressure in young adults.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Skin renin-angiotensin system: a potential therapeutic target for the management of hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- The skin renin-angiotensin system and hypertension: A TRAP for blood flow capture and water release.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Dark-phase melatonin administration does not reduce blood pressure but induces changes in parameters related to the control of the cardiovascular system in spontaneously hypertensive rats.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Keratinocyte-specific angiotensin II receptor-associated protein deficiency exacerbates angiotensin II-dependent hypertension via activation of the skin renin-angiotensin system.Nature communications · 2025Article
- Blood pressure alteration associated with abnormal body electrolyte and water balance in colitis mice.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Metabolomic pattern associated with physical sequelae in patients presenting with respiratory symptoms validates the aestivation concept in dehydrated patients.Physiological genomics · 2024Article
- Long-term health outcomes associated with hydration status.Nature reviews. Nephrology · 2024Review
- 2023 update and perspectives.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- Skin microcirculation and hypertension: is there a connection?Jornal brasileiro de nefrologiaReview
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Authors and funding
10 authors at 3 institutions in 4 countries.
Funding
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Abstract
We recently reported that skin vasoconstriction to suppress transepidermal water loss (TEWL) leads to hypertension in renal injury model rats with impaired urine concentration ability. In this study, we investigated the pathogenesis of hypertension in spontaneously hypertensive rats (SHRs) from the perspective of renal water loss and skin water conservation. We compared the urinary concentration ability, body sodium and water balance, blood pressure, and TEWL in SHRs and control normotensive Wistar-Kyoto rats (WKYs). SHRs showed significantly higher urine volume and lower urinary osmolality than those of WKYs, while there were no significant differences in water intake, urinary osmolyte excretion, and plasma osmolarity between the groups. SHRs exhibited significantly higher blood pressure, skin sodium content, and lower TEWL compared with those is WKYs. Skin vasodilation, induced by elevating body temperature, increased TEWL in both SHRs and WKYs, and significantly reduced blood pressure in SHRs but not WKYs. These findings suggest that physiological adaptation can reduce dermal water loss in SHRs to compensate for renal water loss. Vasoconstriction required for successful cutaneous water conservation explains SHR hypertension. Renal concentration ability and skin barrier function for water conservation may become a novel therapeutic target for essential hypertension.
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