ArticleNature communications2022
Structural and functional analysis of EntV reveals a 12 amino acid fragment protective against fungal infections.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- Multidrug Resistance and Host Adaptation in Candida Auris: From Molecular Mechanisms to Emerging Therapeutic Frontiers.Mycopathologia · 2026Review
- α-Helical peptides: design strategies and recent advances in biomedical applications.Journal of translational medicine · 2026Review
- Article
- Bacteriocins fromFrontiers in microbiology · 2026Review
- Gut bacteria: protective mediators, pathogenic contributors and novel therapeutic targets in Candida albicans infections.Gut pathogens · 2025Review
- The antifungal mechanism of EntV-derived peptides is associated with a reduction in extracellular vesicle release.PLoS pathogens · 2025Article
- Diagnostic and Therapeutic Challenge Caused byPathogens (Basel, Switzerland) · 2024Review
- Bacteriocin diversity, function, discovery and application as antimicrobials.Nature reviews. Microbiology · 2024Review
- Vertebrate and invertebrate animal infection models of Candida auris pathogenicity.Current opinion in microbiology · 2024Review
- Detecting co-selection through excess linkage disequilibrium in bacterial genomes.NAR genomics and bioinformatics · 2024Article
- Optimization of the antifungal properties of the bacterial peptide EntV by variant analysis.mBio · 2024Article
- Candida-bacterial cross-kingdom interactions.Trends in microbiology · 2023Review
- Antifungal therapy ofBiofilm · 2023Article
- Commensal fungi in intestinal health and disease.Nature reviews. Gastroenterology & hepatology · 2023Review
- The biofilm community resurfaces: new findings and post-pandemic progress.Journal of bacteriology · 2023Review
- Host-derived reactive oxygen species trigger activation of the Candida albicans transcription regulator Rtg1/3.PLoS pathogens · 2023Article
- Interplay between host and Candida albicans during commensal gut colonization.PLoS pathogens · 2023Article
- Advances in the treatment of invasive fungal disease.PLoS pathogens · 2023Review
- A Toll pathway effector protectsProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Theoretical Study at the Molecular Mechanics Level of the Interaction of Tetracycline and Chloramphenicol with the Antibiotic Receptors Present inAntibiotics (Basel, Switzerland) · 2022Article
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Authors and funding
15 authors at 6 institutions in 2 countries.
Funding
Abstract
Fungal pathogens are a continuing challenge due to few effective antifungals and a rise in resistance. In previous work, we described the inhibition of Candida albicans virulence following exposure to the 68 amino acid bacteriocin, EntV, secreted by Enterococcus faecalis. Here, to optimize EntV as a potential therapeutic and better understand its antifungal features, an X-ray structure is obtained. The structure consists of six alpha helices enclosing a seventh 16 amino acid helix (α7). The individual helices are tested for antifungal activity using in vitro and nematode infection assays. Interestingly, α7 retains antifungal, but not antibacterial activity and is also effective against Candida auris and Cryptococcus neoformans. Further reduction of α7 to 12 amino acids retains full antifungal activity, and excellent efficacy is observed in rodent models of C. albicans oropharyngeal, systemic, and venous catheter infections. Together, these results showcase EntV-derived peptides as promising candidates for antifungal therapeutic development.
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Registered trials
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