Evidence map›Paper›PMID 36229414›Full record

ArticleBMB reports2022

Dikkopf-1 promotes matrix mineralization of osteoblasts by regulating Ca

Hyosun Park, Sungsin Jo, Mi-Ae Jang, Sung Hoon Choi, Tae-Hwan Kim

Open access · greenAbstract readNews
PubMed Full text at PMC
In one paragraph

Article in BMB reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Hyosun ParkHanyang University Institute for Rheumatology Research, Seoul 04763; Department of Translational Medicine, Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul 04763, Korea.
Sungsin JoHanyang University Institute for Rheumatology Research, Seoul 04763, Korea.
Mi-Ae JangDepartment of Laboratory Medicine and Genetics, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon 14584, Kroea.
Sung Hoon ChoiDepartment of Orthopedic Surgery, Hanyang University Seoul Hospital, Seoul 04763, Korea.
Tae-Hwan KimHanyang University Institute for Rheumatology Research, Seoul 04763; Department of Translational Medicine, Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul 04763; Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul 04763, Korea.
Hanyang University · KRHanyang University Seoul Hospital · KRSoonchunhyang University · KRSoonchunhyang University Hospital Seoul · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dickkopf-1 (DKK1) is a secreted protein that acts as an antagonist of the canonical WNT/β-catenin pathway, which regulates osteoblast differentiation. However, the role of DKK1 on osteoblast differentiation has not yet been fully clarified. Here, we investigate the functional role of DKK1 on osteoblast differentiation. Primary osteoprogenitor cells were isolated from human spinal bone tissues. To examine the role of DKK1 in osteoblast differentiation, we manipulated the expression of DKK1, and the cells were differentiated into mature osteoblasts. DKK1 overexpression in osteoprogenitor cells promoted matrix mineralization of osteoblast differentiation but did not promote matrix maturation. DKK1 increased Ca

Indexed as

Calcification, PhysiologicCyclic AMP Response Element-Binding ProteinIntercellular Signaling Peptides and ProteinsOsteoblastsbeta CateninCalcium-Calmodulin-Dependent Protein Kinase Type 2Cell DifferentiationCell LineHumansProtein Serine-Threonine Kinasesbeta CateninCalcium-Calmodulin-Dependent Protein Kinase Type 2CAMK2A protein, humanCREB1 protein, humanCyclic AMP Response Element-Binding ProteinDKK1 protein, humanIntercellular Signaling Peptides and ProteinsProtein Serine-Threonine Kinases

Identifiers

PMID36229414
PMCPMC9813425
OpenAlexW4283272368

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.