Trial reportBehavior therapy2022
Childhood Predictors of Long-Term Tic Severity and Tic Impairment in Tourette's Disorder.
Trial report in Behavior therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- The relationship between sensory phenomena and interoception across the obsessive-compulsive spectrum: a systematic review.BMC psychiatry · 2025Pooled it
- Premonitory urge in tic disorders - a scoping review.Frontiers in psychiatry · 2025Pooled it
- Childhood cognitive control as a predictor of long-term clinical and functional outcomes in Tourette syndrome.Journal of child psychology and psychiatry, and allied disciplines · 2026Trial
- Tourette syndrome.Nature reviews. Disease primers · 2026Review
- Metabolic abnormalities of the cortico‑striato‑thalamo‑cortical circuit of rats with tic disorder.Molecular medicine reports · 2025Article
- Subtypes of tic disorders in children and adolescents: based on clinical characteristics.BMC pediatrics · 2025Article
- Evidence-Based Behavior Therapy for Tourette Syndrome.The Psychiatric clinics of North America · 2025Review
- Longitudinal and cross-sectional predictors of sleep disturbance in a treatment follow-up sample with Tourette's disorder.Frontiers in psychiatry · 2025Article
- Altered network connectivity and global efficiency in tourette syndrome: insights into sensorimotor integration.NeuroImage. Clinical · 2025Article
- The clinical features and initial pharmacotherapeutic options of children with Tic disorders.Frontiers in pediatrics · 2025Article
- Transcranial magnetic stimulation to probe the role of the supplementary motor area in tics.Frontiers in human neuroscience · 2025Article
- Perspectives from Adults with Tourette Syndrome on Research Priorities and Registry Development: A Focus Group Study.Neuropsychiatric disease and treatment · 2024Article
- New insights of metabolite abnormalities in the thalamus of rats with iminodiproprionitrile-induced tic disorders.Frontiers in neuroscience · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 10 institutions in 1 country.
Funding
Abstract
Tics peak in late childhood and decline during adolescence. Yet, for some with Tourette's disorder, tics persist into adulthood. We evaluated childhood predictors of adult tic severity and tic impairment, and change over time. Eighty adolescents/adults were evaluated 11 years following a randomized-controlled trial of behavior therapy. An independent evaluator rated tic severity and tic impairment at baseline, posttreatment, and long-term follow-up. At baseline, parents completed demographics/medical history, and youth tic, internalizing, and externalizing symptom ratings. Youth rated premonitory urge severity and family functioning. After controlling for prior tic treatment effects, female sex and higher tic severity predicted higher tic severity in adulthood; and female sex, no stimulant medication use, higher tic severity, and poorer family functioning predicted higher tic impairment. Higher tic severity and premonitory urge severity predicted smaller reductions in tic severity, whereas higher externalizing symptoms predicted greater reduction in tic severity. Female sex predicted smaller reduction in tic impairment, and externalizing symptoms predicted greater reduction in tic impairment. Female sex and childhood tic severity are important predictors of tic severity and tic impairment in adulthood. Family functioning, premonitory urge severity, and tic severity are important modifiable targets for early or targeted intervention to improve long-term outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.