Observational studyThe European respiratory journal2023
Clinical outcomes of bronchiectasis in India: data from the EMBARC/Respiratory Research Network of India registry.
Observational study in The European respiratory journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
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Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- A systematic literature review of the clinical and socioeconomic burden of bronchiectasis.European respiratory review : an official journal of the European Respiratory Society · 2024Pooled it
- Eradication treatment forEuropean respiratory review : an official journal of the European Respiratory Society · 2024Pooled it
- Efficacy and Safety of Brensocatib in Participants of Asian Race with Non-cystic Fibrosis Bronchiectasis: A Subgroup Analysis of the ASPEN Trial.Pulmonary therapy · 2026Article
- Article
- The bacteriology of bronchiectasis patients and relation to disease severity.BMC pulmonary medicine · 2026Article
- Factors associated with bronchiectasis in Sri Lanka: evidence from a multicenter case-control study in the Colombo District.BMC pulmonary medicine · 2026Article
- Association of German Bronchiectasis Registry participation with disease course.ERJ open research · 2026Article
- A 67-year-old woman with bronchiectasis and acute worsening respiratory symptoms.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026Article
- The European Respiratory Society guideline for management of adult bronchiectasis: clinical summary.Breathe (Sheffield, England) · 2026Review
- Brensocatib-Another Therapeutic "Window of Opportunity" for Patients with Bronchiectasis.Journal of clinical medicine · 2026Review
- Greater disease severity in adults with paediatric-onsetThe European respiratory journal · 2026Article
- Precision diagnostics in bronchiectasis: current advances in imaging, microbiology, biomarkers, and digital health.Frontiers in medicine · 2026Review
- Serum TNF-α and the future of biomarker-enhanced prognostication in bronchiectasis: An Indian perspective.Lung India : official organ of Indian Chest Society · 2026Article
- From evidence to practice: What the 2025 European Respiratory Society Bronchiectasis Guideline means for India.Lung India : official organ of Indian Chest Society · 2026Article
- Risk factors and prediction model for chronic bacterial infection in stable bronchiectasis in Shanghai, China.Frontiers in medicine · 2026Article
- Integrated multi-omics profiling for risk stratification in Asians with COPD.Respiratory research · 2025Article
- Considerations in the Diagnosis and Management of Bronchiectasis in Older Adults.Clinics in geriatric medicine · 2025Review
- What is the optimal dose of N-acetylcysteine in adult patients with bronchiectasis?-data from the RIBRON registry.Journal of thoracic disease · 2025Article
- Non-cystic fibrosis bronchiectasis in Taiwan.BMJ open respiratory research · 2025Observational
- Use of long-term inhaled antibiotics and macrolides: insights from the four global bronchiectasis registries.Journal of thoracic disease · 2025Article
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Authors and funding
64 authors at 20 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIdentifying risk factors for poor outcomes can help with risk stratification and targeting of treatment. Risk factors for mortality and exacerbations have been identified in bronchiectasis but have been almost exclusively studied in European and North American populations. This study investigated the risk factors for poor outcome in a large population of bronchiectasis patients enrolled in India.
methodsThe European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC) and Respiratory Research Network of India (EMBARC-India) registry is a prospective observational study of adults with computed tomography-confirmed bronchiectasis enrolled at 31 sites across India. Baseline characteristics of patients were used to investigate associations with key clinical outcomes: mortality, severe exacerbations requiring hospital admission, overall exacerbation frequency and decline in forced expiratory volume in 1 s.
results1018 patients with at least 12-month follow-up data were enrolled in the follow-up study. Frequent exacerbations (≥3 per year) at baseline were associated with an increased risk of mortality (hazard ratio (HR) 3.23, 95% CI 1.39-7.50), severe exacerbations (HR 2.71, 95% CI 1.92-3.83), future exacerbations (incidence rate ratio (IRR) 3.08, 95% CI 2.36-4.01) and lung function decline. Coexisting COPD, dyspnoea and current cigarette smoking were similarly associated with a worse outcome across all end-points studied. Additional predictors of mortality and severe exacerbations were increasing age and cardiovascular comorbidity. Infection with Gram-negative pathogens (predominantly
conclusionsThis study identifies risk factors for morbidity and mortality among bronchiectasis patients in India. Identification of these risk factors may support treatment approaches optimised to an Asian setting.
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