Evidence map›Paper›PMID 36228919›Full record

ArticleThe American journal of tropical medicine and hygiene2022

Advances in Basic and Translational Research as Part of the Center for the Study of Complex Malaria in India.

Jane M Carlton, Alex Eapen, Anne Kessler, Anupkumar R Anvikar, Angelika Hoffmann, Om P Singh, Steven A Sullivan, Sandra Albert, Praveen K Sahu, Sanjib Mohanty and 1 more

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07770048 (The Center for the Study of Complex Malaria in India), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07770048 recruitingnot on this mapstarted 2025, after this paper: background citation

The Center for the Study of Complex Malaria in India (CSCMi 3.0): Hidden Plasmodium Infections: Reservoirs, Impact, and Biomarker Discovery

TypeobservationalSponsorLondon School of Hygiene and Tropical MedicineRan2025 to 2029Enrolled3,000ConditionsMalaria, Asymptomatic Parasitaemia
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 4 countries.

Jane M CarltonCenter for Genomics and Systems Biology, Department of Biology, New York University, New York, New York.
Alex EapenNational Institute of Malaria Research, Indian Council of Medical Research, IDVC Field Unit, National Institute of Epidemiology Campus, Chennai, Tamil Nadu, India.
Anne KesslerCenter for Genomics and Systems Biology, Department of Biology, New York University, New York, New York.
Anupkumar R AnvikarNational Institute of Biologicals, Ministry of Health and Family Welfare, Government of India, Noida, Uttar Pradesh, India.
Angelika HoffmannUniversity Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, University of Bern, Switzerland.
Om P SinghNational Institute of Malaria Research, Indian Council of Medical Research, Dwarka, Delhi, India.
Steven A SullivanCenter for Genomics and Systems Biology, Department of Biology, New York University, New York, New York.
Sandra AlbertIndian Institute of Public Health Shillong, Shillong, Meghalaya, India.
Praveen K SahuDepartment of Molecular and Infectious Diseases, Community Welfare Society Hospital, Rourkela, Odisha, India.
Sanjib MohantyDepartment of Molecular and Infectious Diseases, Community Welfare Society Hospital, Rourkela, Odisha, India.
Samuel C WassmerDepartment of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
New York University · USCommunity Welfare Society HospitalNational Institute of Malaria Research · INLondon School of Hygiene & Tropical Medicine · GBMartin Luther Christian University · INMinistry of Health and Family Welfare · INUniversity Hospital of Bern · CH

Funding

Using Next-Generation Genomics to Study Antimalarial Drug Resistance in IndiaU19AI089676 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CARLTON, JANE M · 2010 to 2023
$22.6M
Medical Research Council MR/S009450/1NIAID NIH HHS U19 AI089676
6 · The paper itself

Abstract

The Center for the Study of Complex Malaria in India (CSCMi) is one of 10 International Centers of Excellence in Malaria Research funded by the National Institutes of Health since 2010. The Center combines innovative research with capacity building and technology transfer to undertake studies with clinical and translational impact that will move malaria control in India toward the ultimate goal of malaria elimination/eradication. A key element of each research site in the four states of India (Tamil Nadu, Gujarat, Odisha, and Meghalaya) has been undertaking community- and clinic-based epidemiology projects to characterize the burden of malaria in the region. Demographic and clinical data and samples collected during these studies have been used in downstream projects on, for example, the widespread use of mosquito repellants, the population genomics of Plasmodium vivax, and the serological responses to P. vivax and Plasmodium falciparum antigens that reflect past or present exposure. A focus has been studying the pathogenesis of severe malaria caused by P. falciparum through magnetic resonance imaging of cerebral malaria patients. Here we provide a snapshot of some of the basic and applied research the CSCMi has undertaken over the past 12 years and indicate the further research and/or clinical and translational impact these studies have had.

Indexed as

MalariaMalaria, FalciparumMalaria, VivaxAnimalsHumansIndiaPlasmodium falciparumPlasmodium vivaxTranslational Research, Biomedical

Identifiers

PMID36228919
PMCPMC9662212
OpenAlexW4306154162

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.