Evidence map›Paper›PMID 36228915›Full record

ArticleThe American journal of tropical medicine and hygiene2022

Understanding the Intransigence of Malaria in Malawi.

Lauren M Cohee, Jessy Goupeyou-Youmsi, Karl B Seydel, Charles Mangani, Peter Ntenda, Alick Sixpence, Rex B Mbewe, Alfred Matengeni, Shannon Takala-Harrison, Edward D Walker and 6 more

Open access · hybridAbstract read
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

Lauren M CoheeCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland.
Jessy Goupeyou-YoumsiMalaria Alert Centre, Kamuzu University of Health Sciences, Blantyre, Malawi.
Karl B SeydelDepartment of Osteopathic Medical Specialties, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan.
Charles ManganiSchool of Public Health, Kamuzu University of Health Sciences, Blantyre, Malawi.
Peter NtendaMalaria Alert Centre, Kamuzu University of Health Sciences, Blantyre, Malawi.
Alick SixpenceMalaria Alert Centre, Kamuzu University of Health Sciences, Blantyre, Malawi.
Rex B MbeweDepartment of Physics and Biochemical Sciences, Malawi University of Business and Applied Sciences, Blantyre, Malawi.
Alfred MatengeniMalaria Alert Centre, Kamuzu University of Health Sciences, Blantyre, Malawi.
Shannon Takala-HarrisonCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland.
Edward D WalkerDepartment of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan.
Mark L WilsonDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan.
Themba MzilahowaMalaria Alert Centre, Kamuzu University of Health Sciences, Blantyre, Malawi.
Miriam K LauferCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland.
Clarissa ValimDepartment of Global Health, Boston University School of Public Health, Boston, Massachusetts.
Terrie E TaylorDepartment of Osteopathic Medical Specialties, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan.
Don P MathangaMalaria Alert Centre, Kamuzu University of Health Sciences, Blantyre, Malawi.
Kamuzu Central Hospital · MWMichigan State University · USUniversity of Maryland, Baltimore · USBoston University · USKamuzu University of Health SciencesUniversity of Michigan–Ann Arbor · US

Funding

The role of monocytes in the pathology of severe malaria.U19AI089683 · NIAID · MICHIGAN STATE UNIVERSITY · PI SEYDEL, KARL BOYNTON · 2010 to 2023
$21.4M
Interdisciplinary malaria research training in MalawiD43TW010075 · FIC · UNIVERSITY OF MARYLAND BALTIMORE · PI LAUFER, MIRIAM K., MATHANGA, DON P · 2016 to 2021
$1.1M
Characterizing malaria vector competence among natural populations of AnophelesR21AI156297 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI LAUFER, MIRIAM K., MZILAHOWA, THEMBA · 2021 to 2022
$393k
FIC NIH HHS D43 TW010075NIAID NIH HHS R21 AI156297NIAID NIH HHS U19 AI089683
6 · The paper itself

Abstract

Despite the scale-up of interventions against malaria over the past decade, this disease remains a leading threat to health in Malawi. To evaluate the epidemiology of both Plasmodium falciparum infection and malaria disease, the Malawi International Center of Excellence for Malaria Research (ICEMR) has developed and implemented diverse and robust surveillance and research projects. Descriptive studies in ICEMR Phase 1 increased our understanding of the declining effectiveness of long-lasting insecticidal nets (LLINs), the role of school-age children in malaria parasite transmission, and the complexity of host-parasite interactions leading to disease. These findings informed the design of ICEMR Phase 2 to test hypotheses about LLIN use and effectiveness, vector resistance to insecticides, demographic targets of malaria control, patterns and causes of asymptomatic to life-threatening disease, and the impacts of RTS,S vaccination plus piperonyl butoxide-treated LLINs on infection and disease in young children. These investigations are helping us to understand mosquito-to-human and human-to-mosquito transmission in the context of Malawi's intransigent malaria problem.

Indexed as

InsecticidesInsecticide-Treated BednetsMalariaAnimalsChildChild, PreschoolHumansInsecticide ResistanceMalawiMosquito ControlMosquito VectorsPiperonyl ButoxideInsecticidesPiperonyl Butoxide

Identifiers

PMID36228915
PMCPMC9662216
OpenAlexW4306154040

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.