Evidence map›Paper›PMID 36228656›Full record

ArticleNature2022

Structural principles of B cell antigen receptor assembly.

Ying Dong, Xiong Pi, Frauke Bartels-Burgahn, Deniz Saltukoglu, Zhuoyi Liang, Jianying Yang, Frederick W Alt, Michael Reth, Hao Wu

Open access · greenAbstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 85 citations in OpenAlex.

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  20. Dynamics and Activation of Membrane-Bound B Cell Receptor Assembly.bioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Ying Dong *Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Xiong Pi *Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8835-6914
Frauke Bartels-BurgahnSignaling Research Centers BIOSS and CIBSS, Freiburg, Germany.
Deniz SaltukogluSignaling Research Centers BIOSS and CIBSS, Freiburg, Germany.
Zhuoyi LiangProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Jianying YangSignaling Research Centers BIOSS and CIBSS, Freiburg, Germany.
Frederick W AltProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0583-1271
Michael RethSignaling Research Centers BIOSS and CIBSS, Freiburg, Germany. michael.reth@bioss.uni-freiburg.de.ORCID http://orcid.org/0000-0002-1025-7198
Hao WuDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. wu@crystal.harvard.edu.ORCID http://orcid.org/0000-0002-7281-8579
Boston Children's Hospital · USUniversity of Freiburg · DE

Funding

Pacific Northwest Center for Cryo-EM - Screening supplementU24GM129547 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI EVANS, JAMES E, GOUAUX, JAMES E · 2018 to 2023
$54.8M
Antigen recognition and activation of HIV-specific B cell antigen receptorsR01AI145656 · NIAID · DUKE UNIVERSITY · PI S. Munir ALAM, Laurent Karl Verkoczy · 2019 to 2026
$7.7M
SMOCs: Novel Signal Transduction Complexes as New Targets for Drug DiscoveryDP1HD087988 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI WU, HAO · 2015 to 2019
$4.4M
NIAID NIH HHS R01 AI145656NICHD NIH HHS DP1 HD087988NIGMS NIH HHS U24 GM129547
6 · The paper itself

Abstract

The B cell antigen receptor (BCR) is composed of a membrane-bound class M, D, G, E or A immunoglobulin for antigen recognition

Indexed as

Cryoelectron MicroscopyReceptors, Antigen, B-CellAnimalsB-LymphocytesImmunoglobulin Fab FragmentsMicePhosphorylationProtein DomainsSignal TransductionImmunoglobulin Fab FragmentsReceptors, Antigen, B-Cell

Identifiers

PMID36228656
PMCPMC10499536
OpenAlexW4305014647

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.