ArticlePloS one2022
Associations of hyponatremia and SIADH with increased mortality, young age and infection parameters in patients with tuberculosis.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 9 citations in OpenAlex.
- Development and validation of a primary care-accessible risk prediction model for severe pulmonary TB.IJTLD open · 2026Article
- Comparative Clinical Characteristics of ICU and Non-ICU Hospitalized Patients With Human Anaplasmosis.Open forum infectious diseases · 2026Article
- Escaped surveillance: tuberculosis masked by severe hyponatremia in an immunocompromised patient: a case report.Journal of medical case reports · 2026Article
- Machine learning prediction of tuberculosis mortality: a comparative analysis of random survival forest and cox regression models.BMC infectious diseases · 2026Article
- Development and validation of a preliminary multivariable diagnostic model for identifying unusual infections in hospitalized patients.Biomolecules & biomedicine · 2024Article
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12 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveHyponatremia and the syndrome of inappropriate antidiuretic hormone secretion (SIADH) are associated with and can be caused by tuberculosis (TB) through meningitis by locally invading the hypothalamus, adrenal, or pituitary glands or possibly through ectopic ADH production. This study assessed the association of TB mortality with hyponatremia and SIADH in a large cohort of a university hospital in Austria.
methodsThis retrospective study enrolled patients with hyponatremia and patients diagnosed with TB from 01/2001-11/2019 to assess the prevalence of TB in hyponatremia and TB morbidity and mortality in patients with and without hyponatremia. Sex, age, microbiological results, laboratory tests and comorbidities were analysed and used to calculate survival rates.
resultsOf 107.532 patients with hyponatremia (0.07%) and 186 patients with TB (43%), 80 patients were diagnosed with both-hyponatremia and TB. Only three TB patients had SIADH, precluding further SIADH analysis. In hyponatremia, young age and high CRP levels showed significant associations with TB diagnosis (p<0.0001). Survival rates of patients diagnosed with TB with moderate to profound hyponatremia were significantly lower than those without hyponatremia (p = 0.002).
conclusionIn this study of a large cohort from a tertiary care hospital in a non-endemic area of TB, 0.07% of patients presenting with hyponatremia, but especially younger patients and patients with high CRP values, were diagnosed with TB. Crucially, patients with moderate to profound hyponatremia had a significantly higher mortality rate and thus required increased medical care.
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