Evidence map›Paper›PMID 36227844›Full record

Observational studyPLoS neglected tropical diseases2022

Community-based wound management in a rural setting of Côte d'Ivoire.

Simone Toppino, Didier Yao Koffi, Bognan Valentin Kone, Raymond T A S N'Krumah, Ismaël Dognimin Coulibaly, Frank Tobian, Gerd Pluschke, Marija Stojkovic, Bassirou Bonfoh, Thomas Junghanss

Registry-linked trialOpen access · goldAbstract readObservational Study
In one paragraph

Observational study in PLoS neglected tropical diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03957447 (Treat Early and Broad), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03957447 unknown statusnot on this map

Treat Early and Broad: Thermotherapy of Buruli Ulcer Integrated Into WHO-recommended Wound Management in West Africa

TypeobservationalSponsorUniversity Hospital HeidelbergRan2019 to 2024Enrolled5,000ConditionsSkin Ulcer, Buruli Ulcer, Nontuberculous MycobacteriaArmsthermotherapy (application of heat): This part of the trial is on hold due to the Covid19-pandemia
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Simone ToppinoDivision Infectious Diseases and Tropical Medicine, Heidelberg University Hospital, Heidelberg, Germany.ORCID 0000-0002-0576-8241
Didier Yao KoffiCentre Suisse de Recherches Scientifiques en Côte d'Ivoire, Abidjan, Côte d'Ivoire.
Bognan Valentin KoneCentre Suisse de Recherches Scientifiques en Côte d'Ivoire, Abidjan, Côte d'Ivoire.
Raymond T A S N'KrumahCentre Suisse de Recherches Scientifiques en Côte d'Ivoire, Abidjan, Côte d'Ivoire.
Ismaël Dognimin CoulibalyCentre Suisse de Recherches Scientifiques en Côte d'Ivoire, Abidjan, Côte d'Ivoire.
Frank TobianDivision Infectious Diseases and Tropical Medicine, Heidelberg University Hospital, Heidelberg, Germany.
Gerd PluschkeMolecular Immunology Unit, Swiss Tropical and Public Health Institute, Basel, Switzerland.
Marija StojkovicDivision Infectious Diseases and Tropical Medicine, Heidelberg University Hospital, Heidelberg, Germany.
Bassirou BonfohCentre Suisse de Recherches Scientifiques en Côte d'Ivoire, Abidjan, Côte d'Ivoire.
Thomas JunghanssDivision Infectious Diseases and Tropical Medicine, Heidelberg University Hospital, Heidelberg, Germany.
Heidelberg University · DESwiss Centre for Scientific Research · CIUniversité Pelefero Gon Coulibaly · CISwiss Tropical and Public Health Institute · CH

Funding

EPA EP-C-15-008
6 · The paper itself

Abstract

backgroundWounds are a neglected health problem in rural communities of low-income countries, mostly caused by trauma and ulcerative skin diseases including Neglected Tropical Diseases (NTDs) and associated with systemic complications and disability. Rural communities have limited access to high quality health services-based wound care.

methodsWe conducted a prospective observational study on wound management at three levels-community (C), health centre (HC), district hospital (DH)-in a rural community of Côte d'Ivoire. Patients with skin wounds actively identified in a house-to-house survey and passively in the health services in a defined area of the Taabo Health and Demographic Surveillance System were asked to participate and followed-up longitudinally. Endpoints were proportion of wounds closed, time to wound closure, wound size over time, frequency of secondary bacterial infection, need for recapturing after follow-up interruption, and duration of treatment stratified by health service level and wound aetiology.

resultsWe enrolled 561 patients with 923 wounds between May 2019 and March 2020. The observation period ended in March 2021. Median age was 10 years (IQR 7-15), 63.0% of patients were male. Almost all (99.5%, 870/874) wounds closed within the observation period, 5.3% (49/923) were lost to follow-up. Wounds primarily treated in C, HC and DH closed within a median time of 10, 16 and 170 days, respectively. Median time to acute wound and chronic wound closure was 13 and 72 days, respectively. Wounds treated in C, HC and DH presented with secondary bacterial infections in 10.3% (36/350), 31.0% (133/429) and 100% (5/5) of cases, respectively. Recapturing was required in 68.3% (630/923) of wounds with participants reporting wound closure as the main reason for not attending follow-up.

conclusionsWe describe a wound management model based on national and WHO recommendations focusing on early identification and treatment in the community with potential for broad implementation in low-income countries.

trial registrationRegistration at ClinicalTrials.gov (NCT03957447).

Indexed as

Neglected DiseasesRural PopulationChildCote d'IvoireFemaleHealth ServicesHumansMaleSurveys and Questionnaires

Identifiers

PMID36227844
PMCPMC9560516
OpenAlexW4305057737

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.