ArticleProbiotics and antimicrobial proteins2023
Evaluation of Antifungal Metabolites Produced by Lactic Acid Bacteria.
Article in Probiotics and antimicrobial proteins, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 20 citations in OpenAlex.
- Effect of lactic acid bacterial starter Pediococcus acidilactici KUB-M6 on corn stover silage quality: microbial and biochemical properties.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Functional Properties of Lactic Acid Bacteria Postbiotics Isolated from Tarhana Samples.Probiotics and antimicrobial proteins · 2026Article
- Bio-Functional Properties of Lactic Acid Bacteria in Functional Foods.Foods (Basel, Switzerland) · 2026Article
- The Influence of the Conditions of Cultivation of Lactic Acid Bacteria on Their Antagonistic Activity Against Some Plant Pathogenic Bacteria.Plant direct · 2025Article
- Jujube powder supplementation optimized high-moisture alfalfa silage through regulating microbial community.Frontiers in microbiology · 2025Article
- In Vitro Anti-Microorganisms · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to select and characterize lactic acid bacteria (LAB) with potential antifungal activities against the filamentous fungi Alternaria alternata ATCC MYA-4642, Aspergillus flavus KACC 45470, Aspergillus niger KACC 42589, Cladosporium sphaerospermum ATCC MYA-4645, Penicillium chrysogenum ATCC MYA-4644, and Penicillium expansum KACC 40815. Initial screening of the antifungal activity has identified six LAB strains belonging to the genera Enterococcus and Leuconostoc, selected by their antagonistic activities against at least three of the filamentous fungi in the test panel. Preliminary prediction of bioactive compounds was carried out to narrow down the possible identity of the antagonistic metabolites produced by the studied LAB. Furthermore, metabolic profiles were assessed and used as a basis for the identification of key metabolites based on VIP scores and PCA plot scores. Key metabolites were identified to be β-phenyllactic acid, ⍺-hydroxyisobutyric acid, 1,3-butanediol, phenethylamine, and benzoic acid. Individual assessment of each metabolic compound against the test panel showed specificity inhibitory patterns; yet, combinations between them only showed additive, but not synergetic effects. The pH neutralization significantly reduced the antifungal activity of the cell-free supernatant (CFS), but no bioactive compounds were found to be stable in high temperatures and pressure. This study will be beneficial as an additional building block on the existing knowledge and future antifungal application of LAB produced metabolites. Furthermore, this study also provides a new bio-preservative perspective on unexplored antifungal metabolites produced by LAB as biocontrol agents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.