ArticleHepatology international2023
Association of age at first birth and risk of non-alcoholic fatty liver disease in women: evidence from the NHANES.
Article in Hepatology international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 16 citations in OpenAlex.
- Article
- Causal effect of potential risk factors on obstructive sleep apnea: a Mendelian randomization study.Future science OA · 2025Article
- Nonlinear Relationship Between Triglyceride-to-High-Density Lipoprotein Cholesterol Ratio and Non-Alcoholic Fatty Liver Disease: A Secondary Retrospective Analysis Based on a Japanese Longitudinal Study.Journal of clinical laboratory analysis · 2025Article
- Association between age at first birth and cognitive function in women 60 years and older: the 2011-2014 cross-sectional National Health and Nutrition Examination Survey (NHANES) study.BMC public health · 2025Article
- Associations of Birth Interval With Prevalence of Depression in Postmenopausal Women.Depression and anxiety · 2025Article
- Associations between reproductive factors and the prevalence of depression: findings from the National Health and Nutrition Examination Survey (NHANES) 2005-2018.BMC public health · 2024Article
- Proton pump inhibitor use is associated with increased liver steatosis.Biomedical reports · 2024Article
- Health condition and socioeconomic status mediate the causal effect of reproductive traits on nonalcoholic fatty liver disease: evidence from Mendelian randomization study.Frontiers in endocrinology · 2024Article
- The association of female reproductive factors with risk of metabolic syndrome in women from NHANES 1999-2018.BMC public health · 2023Article
- Association between diet soft drink consumption and metabolic dysfunction-associated steatotic liver disease: findings from the NHANES.BMC public health · 2023Article
- Age at first birth, age at menopause, and risk of ovarian cyst: a two-sample Mendelian randomization study.Frontiers in endocrinology · 2023Article
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10 authors at 5 institutions in 3 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundNumerous studies have suggested that age at first birth (AFB) is inversely associated with metabolic diseases, but positively associated with liver cancer in women. Non-alcoholic fatty liver disease (NAFLD) is a canonical example of metabolic dysfunction and inflammation-based liver disease, while the association between AFB and the risk of NAFLD remains unclear. We aimed to investigate the association between AFB and the odds of NAFLD in women.
methodsWomen older than 20 years at the time of the survey were analyzed using National Health and Nutrition Examination Survey (NHANES) data from 1999 to 2018 in the US. AFB was obtained with self-administered questionnaires. NAFLD was diagnosed as fatty liver index (FLI) ≥ 60. Odds ratios (ORs) and 95% confidence intervals (CI) were estimated using logistic regression models.
resultsOf the 12,188 women included in this study, 5670 (46.5%) had NAFLD. Compared to individuals with AFB of 30-32 years old (reference group), the fully adjusted ORs and 95% CI in women with AFB < 18, 18-20, 21-23, and 24-26 years were 1.52 (95% CI 1.14, 2.03), 1.60 (95% CI 1.21, 2.11), 1.40 (95% CI 1.06, 1.84), and 1.33 (95% CI 1.01-1.76), respectively. Yet there was no significant difference between AFB of 27-29, 33-35, or > 35 years compared to the reference group.
conclusionsWomen with younger AFB have higher odds of NAFLD in later life. Policymakers should consider focusing on those with earlier AFB for screening and prevention of NAFLD.
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