Evidence map›Paper›PMID 36227145›Full record

ArticleThe Journal of physiology2022

Nitrosylation of cardiac CaMKII at Cys290 mediates mechanical afterload-induced increases in Ca

Chidera C Alim, Christopher Y Ko, Juliana Mira Hernandez, Erin Y Shen, Sonya Baidar, Ye Chen-Izu, Donald M Bers, Julie Bossuyt

Open access · hybridAbstract read
In one paragraph

Article in The Journal of physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Sex differences in mitochondrial CaJournal of molecular and cellular cardiology · 2026
    Article
  5. CaPhysiological reports · 2026
    Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Left Ventricular Systolic Dysfunction in NBCe1-B/C-Knockout Mice.International journal of molecular sciences · 2024
    Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Chidera C AlimDepartment of Pharmacology, University of California, Davis, CA, USA.ORCID 0000-0002-5796-8667
Christopher Y KoDepartment of Pharmacology, University of California, Davis, CA, USA.ORCID 0000-0002-4539-8222
Juliana Mira HernandezDepartment of Pharmacology, University of California, Davis, CA, USA.
Erin Y ShenDepartment of Pharmacology, University of California, Davis, CA, USA.
Sonya BaidarDepartment of Pharmacology, University of California, Davis, CA, USA.
Ye Chen-IzuDepartment of Pharmacology, University of California, Davis, CA, USA.ORCID 0000-0003-4818-9570
Donald M BersDepartment of Pharmacology, University of California, Davis, CA, USA.ORCID 0000-0002-2237-9483
Julie BossuytDepartment of Pharmacology, University of California, Davis, CA, USA.
University of California, Davis · USCorporación Universitaria Lasallista · CO

Funding

Project 3 (Mercola)P01HL141084 · NHLBI · STANFORD UNIVERSITY · PI Joseph C. Wu · 2019 to 2026
$21.1M
Pathophysiological Regulation of Cardiac Myocyte RyR ChannelR01HL092097 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Donald M Bers, Robyn T Rebbeck · 2010 to 2026
$9.3M
CaMKII activation and regulation in adult cardiac myocytesR01HL142282 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERS, DONALD M, BOSSUYT, JULIE B · 2018 to 2025
$5.4M
IONIC CONTROL OF CARDIAC MUSCLE CONTRACTION: EC COUPLINGR01HL030077 · NHLBI · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI BERS, DONALD M · 1986 to 2018
$3.8M
MECHANICAL LOAD EFFECT ON CARDIAC EXCITATION-CONTRACTION COUPLINGR01HL141460 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN-IZU, YE · 2019 to 2022
$2.6M
NHLBI NIH HHS P01 HL141084NHLBI NIH HHS R01 HL092097NHLBI NIH HHS R01 HL142282NIH HHS P01-HL141084NIH HHS R01-HL030077NIH HHS R01-HL141460NIH HHS R01-HL142282
6 · The paper itself

Abstract

Cardiac mechanical afterload induces an intrinsic autoregulatory increase in myocyte Ca

Indexed as

Calcium-Calmodulin-Dependent Protein Kinase Type 2Sarcoplasmic ReticulumAnimalsCalciumCalcium SignalingMiceMyocytes, CardiacRyanodine Receptor Calcium Release ChannelCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Ryanodine Receptor Calcium Release ChannelCaMKIIcardiac myocytemechano-chemo-transductionpost-translational modificationsS-nitrosylation

Identifiers

PMID36227145
PMCPMC9827875
OpenAlexW4304975971

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.