Observational studyJournal of intensive care medicine2023
Comparison of Different Ultrasound Methods to Assess Changes in Muscle Mass in Critically ill Patients.
Observational study in Journal of intensive care medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Combined intravenous bolus amino acid supplementation and mobilization on early muscle loss in critically ill adults: A randomized controlled trial.JPEN. Journal of parenteral and enteral nutrition · 2026Trial
- Methodological Approaches for Ultrasound Assessment of Peripheral and Abdominal Muscle Thickness in Intensive Care: A Scoping Review and Proposed Reporting Framework.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026Article
- Peripheral muscle ultrasound in the ICU: current evidence, limitations, and future directions.Intensive care medicine · 2026Article
- Ultrasound assessment of muscle atrophy and its association with functional outcomes in critically ill patients: a systematic review and meta-analysis.Critical care (London, England) · 2026Review
- Open-Source AI for Vastus Lateralis and Adipose Tissue Segmentation to Assess Muscle Size and Quality.Ultrasound in medicine & biology · 2025Article
- Differences in muscle atrophy between the lower limbs and the accessory respiratory muscles in critically ill patients.Journal of medical ultrasonics (2001) · 2025Article
- Impact of ICU Length of Stay and Illness Severity on Rehabilitation Progress and Functional Recovery: A Secondary Analysis of the Japanese Rehabilitation and Risk Factors on the Post-Intensive Care Syndrome (J-RELIFE) Prospective Registry.Critical care explorations · 2025Article
- Development and validation of machine learning-based risk prediction models for ICU-acquired weakness: a prospective cohort study.European journal of medical research · 2025Article
- Article
- Skeletal Muscle Mass Loss Leads to Prolonged Mechanical Ventilation and Higher Tracheotomy Rates in Critically Ill Patients.Journal of clinical medicine · 2024Article
- Methodologies and clinical applications of lower limb muscle ultrasound in critically ill patients: a systematic review and meta-analysis.Annals of intensive care · 2024Review
- Association of tissue oxygen saturation levels with skeletal muscle injury in the critically ill.Scientific reports · 2024Article
- Neuromuscular Ultrasound in Intensive Care Unit-Acquired Weakness: Current State and Future Directions.Medicina (Kaunas, Lithuania) · 2023Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMuscle ultrasound represents a promising approach to aid diagnoses of neuromuscular diseases in critically ill patients. Unfortunately, standardization of ultrasound measurements in clinical research is lacking, making direct comparisons between studies difficult. Protocols are required to assess qualitative muscle changes during an ICU stay in patients at high risk for the development of neuromuscular acquired weakness (ICUAW).
methodsWe conducted a retrospective, observational analysis comprised of three prospective observational studies with the aim of diagnosing muscle changes by ultrasound measurement of the quadriceps muscle. Different protocols were used in each of the three studies. In total, 62 surgical, neurocritical care and trauma intensive care patients were serially assessed by different ultrasound protocols during the first week of critical illness. The relative change in ultrasound measurements was calculated for all possible locations, methods and sides. Comparison was obtained using mixed effect models with the location, the height and the side as influencing variables and patients as fixed effect. The relationship between variables and outcomes was assessed by multivariable regression analysis.
resultsUltrasound methods and measurement sites of the quadriceps muscles from all protocols were equally effective in detecting muscle changes. During the first week of an ICU stay, two groups were identified: patients with decreased muscle mass on ultrasound (n = 42) and a cohort with enlargement (n = 23). Hospital mortality was significantly increased in the cohort with muscle swelling (8 (19%) versus 12 (52%),
conclusionsDifferent approaches of ultrasound measurement during critical-illness are equally able to detect muscle changes. While some patients have a decrease in muscle mass, others show swelling, which may result in a reduced probability of surviving the hospital stay. Causative reasons for these results still remain unclear.
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