Evidence map›Paper›PMID 36226966›Full record

ArticleJournal of bacteriology2022

Shelby J Dechow, Jacob J Baker, Megan Murto, Robert B Abramovitch

Open access · greenAbstract read
In one paragraph

Article in Journal of bacteriology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 20 citations in OpenAlex.

  1. Tyloxapol inhibits ESX-1 secretion inJournal of bacteriology · 2026
    Article
  2. ThemBio · 2026
    Article
  3. mBio · 2026
    Article
  4. Article
  5. Cell envelope maintenance by PhoP is essential forProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. bioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Carbon dioxide regulatesInfection and immunity · 2025
    Article
  13. Article
  14. Article
  15. TargetingMicrobiology (Reading, England) · 2024
    Review
  16. The PDIM paradox ofbioRxiv : the preprint server for biology · 2023
    Article
  17. Article
  18. Article
  19. Proteo-genetic analysis reveals clear hierarchy of ESX-1 secretion inProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Shelby J DechowDepartment of Microbiology and Molecular Genetics, Michigan State Universitygrid.17088.36, East Lansing, Michigan, USA.
Jacob J BakerDepartment of Microbiology and Molecular Genetics, Michigan State Universitygrid.17088.36, East Lansing, Michigan, USA.
Megan MurtoDepartment of Microbiology and Molecular Genetics, Michigan State Universitygrid.17088.36, East Lansing, Michigan, USA.
Robert B AbramovitchDepartment of Microbiology and Molecular Genetics, Michigan State Universitygrid.17088.36, East Lansing, Michigan, USA.ORCID 0000-0002-4119-4169
Michigan State University · US

Funding

Mechanisms of Mycobacterium Tuberculosis pH-driven AdaptationR01AI116605 · NIAID · MICHIGAN STATE UNIVERSITY · PI ABRAMOVITCH, ROBERT B · 2016 to 2020
$1.9M
AgBioResearch, Michigan State University (MSU AgBioResearch)NIAID NIH HHS R01 AI116605
6 · The paper itself

Abstract

In defined media supplemented with single carbon sources, Mycobacterium tuberculosis (Mtb) exhibits carbon source specific growth restriction. When supplied with glycerol as the sole carbon source at pH 5.7, Mtb establishes a metabolically active state of nonreplicating persistence known as acid growth arrest. We hypothesized that acid growth arrest on glycerol is not a metabolic restriction, but rather an adaptive response. To test this hypothesis, we selected for and identified several Mtb mutants that could grow under these restrictive conditions. All mutations were mapped to the

Indexed as

Mycobacterium tuberculosisTuberculosisAcidsCarbonGlycerolHumansHydrogen-Ion ConcentrationAcidsCarbonGlycerolgenetic selectiongrowth regulationMycobacterium tuberculosisnutrient acquisitionpathogenesis

Identifiers

PMID36226966
PMCPMC9664963
OpenAlexW4304957501

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.