Evidence map›Paper›PMID 36226862›Full record

ArticleThe Journal of organic chemistry2023

Synthesis and Conformational Analysis of Hydantoin-Based Universal Peptidomimetics.

Alessio M Caramiello, Maria Cristina Bellucci, Gaetano Cristina, Carlo Castellano, Fiorella Meneghetti, Matteo Mori, Francesco Secundo, Fiorenza Viani, Alessandro Sacchetti, Alessandro Volonterio

Abstract read
In one paragraph

Article in The Journal of organic chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alessio M CaramielloDepartment of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, via Mancinelli 7, 20131Milano, Italy.
Maria Cristina BellucciDepartment of Food, Environmental and Nutritional Sciences, Università degli Studi di Milano, via Celoria 2, 20133Milano, Italy.
Gaetano CristinaDepartment of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, via Mancinelli 7, 20131Milano, Italy.
Carlo CastellanoDepartment of Chemistry, Università degli Studi di Milano, via Golgi 19, 20133Milano, Italy.
Fiorella MeneghettiDepartment of Pharmaceutical Sciences, Università degli Studi di Milano, via Mangiagalli 25, 20133Milano, Italy.ORCID 0000-0002-6511-7360
Matteo MoriDepartment of Pharmaceutical Sciences, Università degli Studi di Milano, via Mangiagalli 25, 20133Milano, Italy.ORCID 0000-0002-7491-1494
Francesco SecundoConsiglio Nazionale delle Ricerche, Istituto di Scienze e Tecnologie Chimiche "G. Natta" (SCITEC), via Mario Bianco 9, 20131Milan, Italy.
Fiorenza VianiConsiglio Nazionale delle Ricerche, Istituto di Scienze e Tecnologie Chimiche "G. Natta" (SCITEC), via Mario Bianco 9, 20131Milan, Italy.
Alessandro SacchettiDepartment of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, via Mancinelli 7, 20131Milano, Italy.ORCID 0000-0002-4830-0825
Alessandro VolonterioDepartment of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, via Mancinelli 7, 20131Milano, Italy.ORCID 0000-0002-0125-0744

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The synthesis of a collection of enantiomerically pure, systematically substituted hydantoins as structural privileged universal mimetic scaffolds is presented. It relies on a chemoselective condensation/cyclization domino process between isocyanates of quaternary or unsubstituted α-amino esters and

Indexed as

HydantoinsPeptidomimeticsCircular DichroismCyclizationModels, MolecularMolecular ConformationSpectroscopy, Fourier Transform InfraredHydantoinsPeptidomimetics

Identifiers

PMID36226862
PMCPMC10407853

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.