Evidence map›Paper›PMID 36226828›Full record

ArticleeLife2022

Antibacterial T6SS effectors with a VRR-Nuc domain are structure-specific nucleases.

Julia Takuno Hespanhol, Daniel Enrique Sanchez-Limache, Gianlucca Gonçalves Nicastro, Liam Mead, Edgar Enrique Llontop, Gustavo Chagas-Santos, Chuck Shaker Farah, Robson Francisco de Souza, Rodrigo da Silva Galhardo, Andrew L Lovering and 1 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Type VI Secretion Systems inMicroorganisms · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. The SPI-20 and SPI-21 T6SS gene clusters fromFrontiers in microbiology · 2026
    Article
  9. Article
  10. Deciphering theJournal of bacteriology · 2025
    Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Genomic analysis ofFrontiers in microbiology · 2024
    Article
  18. Use of Bastion for the Identification of Secreted Substrates.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Julia Takuno Hespanhol *Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0001-6701-7286
Daniel Enrique Sanchez-Limache *Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0003-1364-7527
Gianlucca Gonçalves NicastroDepartamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.
Liam MeadDepartment of Biosciences, University of Birmingham, Birmingham, United Kingdom.
Edgar Enrique LlontopDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0003-4910-9667
Gustavo Chagas-SantosDepartamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.
Chuck Shaker FarahDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil.
Robson Francisco de SouzaDepartamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0002-5284-4630
Rodrigo da Silva GalhardoDepartamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0002-5686-9704
Andrew L LoveringDepartment of Biosciences, University of Birmingham, Birmingham, United Kingdom.
Ethel Bayer-SantosDepartamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0003-3832-3449
Universidade de São Paulo · BRHarvard University · USUniversity of Birmingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The type VI secretion system (T6SS) secretes antibacterial effectors into target competitors.

Indexed as

Bacterial ProteinsType VI Secretion SystemsAnti-Bacterial AgentsEndonucleasesEscherichia coliGenomic IslandsPhylogenyAnti-Bacterial AgentsBacterial ProteinsEndonucleasesType VI Secretion Systemseffectorinfectious diseasemicrobiologynucleaseSalmonellaT6SStoxinVRR-Nuc

Identifiers

PMID36226828
PMCPMC9635880
OpenAlexW4304943972

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.