Evidence map›Paper›PMID 36226814›Full record

ArticleeLife2022

Neuronal temperature perception induces specific defenses that enable

Francesco A Servello, Rute Fernandes, Matthias Eder, Nathan Harris, Olivier M F Martin, Natasha Oswal, Anders Lindberg, Nohelly Derosiers, Piali Sengupta, Nicholas Stroustrup and 1 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  4. CaMK modulates sensory neural activity to control longevity and proteostasis.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Francesco A ServelloBiology Department, Northeastern University, Boston, United States.
Rute FernandesCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Matthias EderCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Nathan HarrisDepartment of Biology, Brandeis University, Waltham, United States.ORCID 0000-0002-7856-520X
Olivier M F MartinCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Natasha OswalCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.ORCID 0000-0003-1478-8356
Anders LindbergBiology Department, Northeastern University, Boston, United States.
Nohelly DerosiersBiology Department, Northeastern University, Boston, United States.
Piali SenguptaDepartment of Biology, Brandeis University, Waltham, United States.ORCID 0000-0001-7468-0035
Nicholas StroustrupCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.ORCID 0000-0001-9530-7301
Javier ApfeldBiology Department, Northeastern University, Boston, United States.ORCID 0000-0001-9897-5671
Universitat Pompeu Fabra · ESBoston University · USBrandeis University · US

Funding

WormBase: a core data resource for C. elegans and other nematodesU41HG002223 · NHGRI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI KERSEY, PAUL, SCHEDL, TIM · 2013 to 2017
$20.5M
Mechanisms of sensory neuron morphological diversification, signaling, and functional plasticityR35GM122463 · NIGMS · BRANDEIS UNIVERSITY · PI Piali Sengupta · 2017 to 2026
$7.7M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Gene regulatory mechanisms underlying temperature-dependent neuronal plasticityF32NS112453 · NINDS · BRANDEIS UNIVERSITY · PI HARRIS, NATHAN CHRISTOPHER STEPHENSON · 2019 to 2021
$161k
Biotechnology and Biological Sciences Research CouncilMedical Research CouncilNHGRI NIH HHS U41 HG002223NIGMS NIH HHS R35 GM122463NIH HHS F32 NS112453NIH HHS P40 OD010440NIH HHS R35 GM122463NINDS NIH HHS F32 NS112453
6 · The paper itself

Abstract

Hydrogen peroxide is the most common reactive chemical that organisms face on the microbial battlefield. The rate with which hydrogen peroxide damages biomolecules required for life increases with temperature, yet little is known about how organisms cope with this temperature-dependent threat. Here, we show that

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsAnimalsHydrogen PeroxidePerceptionSensory Receptor CellsTemperatureCaenorhabditis elegans ProteinsHydrogen PeroxideC. elegansdevelopmental biologyE. coliEnterococcus faeciumhydrogen peroxideinsulin signalingneurosciencesensory perceptiontemperature

Identifiers

PMID36226814
PMCPMC9635881
OpenAlexW4304943575

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.