ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2023
Frailty Transitions in Older Persons With Lung Function Impairment: A Population-Based Study.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Article
- Sarcopenia and Comorbidity Burden Independently Predict Cough Impairment in Hospitalized Patients: A Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Causal effects of physical activity and frailty on pneumothorax risk: a Mendelian randomization study.Archives of medical science : AMS · 2026Article
- Associations of chronic lung disease, insufficient sleep, and pain with incident frailty in Chinese middle-aged and older adults.Epidemiology and health · 2026Article
- Frailty and functional outcomes in patients with progressive fibrosing interstitial lung diseases receiving antifibrotic therapy: a real-life observational study.Frontiers in medicine · 2026Article
- Prognostic Models for Disease Progression and Outcomes in Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Association of Physical Frailty With Incidence and Life Expectancy of COPD: A Population-Based Cohort Study.Chest · 2025Article
- Frailty and COPD: Emphasizing Dynamic Phenotyping and Additive Interaction for Precision Risk Assessment.Chest · 2025Article
- Association between preserved ratio impaired spirometry and frailty risk among US adults: a cross-sectional study.BMJ open · 2025Article
- Association between frailty and frailty change with chronic lung disease: results from two prospective cohort studies.BMC public health · 2025Article
- Relationship Between COPD Progression and Frailty Progression: A Five-year Observation in Real Clinical Practice.International journal of chronic obstructive pulmonary disease · 2025Observational
- Impact of Frailty on Activities of Daily Living and Length of Hospitalization in Acute Exacerbations of Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2025Article
- A trajectory study of postoperative frailty and cognitive function in elderly spinal surgery patients: a cohort study in China.Frontiers in aging neuroscience · 2025Article
- Identifying and Estimating Frailty Phenotypes by Vocal Biomarkers: Cross-Sectional Study.Journal of medical Internet research · 2024Article
- Lung function in relation to brain aging and cognitive transitions in older adults: A population-based cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Developing and validating machine learning-based prediction models for frailty occurrence in those with chronic obstructive pulmonary disease.Journal of thoracic disease · 2024Article
- Lung function and the risk of frailty in the European population: a mendelian randomization study.European journal of medical research · 2024Article
- Analysis of COPD: Distinguishing Characteristics and Management of Smoking vs Never Smoking Patients.International journal of chronic obstructive pulmonary disease · 2024Article
- ERS International Congress 2022: highlights from the Respiratory Clinical Care and Physiology Assembly.ERJ open research · 2023Article
- Rehabilitation for People with Respiratory Disease and Frailty: An Official American Thoracic Society Workshop Report.Annals of the American Thoracic Society · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
backgroundThe aging population and its burden on health care systems warrant early detection of patients at risk of functional decline and mortality. We aimed to assess frailty transitions and its accuracy for mortality prediction in participants with impaired spirometry (Preserved Ratio Impaired Spirometry [PRISm] or chronic obstructive pulmonary disease [COPD]).
methodsIn participants from the population-based Rotterdam Study (mean age 69.1 ± 8.9 years), we examined whether PRISm (forced expiratory volume in 1 second [FEV1]/forced vital capacity [FVC] ≥ 70% and FEV1 < 80%) or COPD (FEV1/FVC < 70%) affected frailty transitions (progression/recovery between frailty states [robust, prefrailty, and frailty], lost to follow-up, or death) using age-, sex- and smoking state-adjusted multinomial regression models yielding odds ratios (OR). Second, we assessed the diagnostic accuracy of frailty score for predicting mortality in participants with COPD using c-statistics.
resultsCompared to participants with normal spirometry, participants with PRISm were more likely to transit from robust (OR 2.2 [1.2-4.2], p < .05) or prefrailty (OR 2.6 [1.3-5.5], p < .01) toward frailty. Participants with PRISm (OR 0.4 [0.2-0.8], p < .05) and COPD (OR 0.6 [0.4-1.0], NS) were less likely to recover from their frail state, and were more likely to progress from any frailty state toward death (OR between 1.1 and 2.8, p < .01). Accuracy for predicting mortality in participants with COPD significantly improved when adding frailty score to age, sex, and smoking status (90.5 [82.3-89.8] vs 77.9 [67.2-88.6], p < .05).
conclusionParticipants with PRISm or COPD more often developed frailty with poor reversibility. Assessing physical frailty improved risk stratification for participants with impaired spirometry for predicting increased life years.
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