ArticlePsychological medicine2023
Mismatch negativity and clinical trajectories in psychotic disorders: Five-year stability and predictive utility.
Article in Psychological medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- A Dual Prediction Error Populations Model of Schizophrenia Spectrum Disorders: Bridging NMDA Hypofunction and Gain Hyperfunction.Schizophrenia bulletin · 2026Article
- Analysis of Task Demand Effects on Visual and Auditory Mismatch Negativity (MMN) Across Autistic and Schizotypal Traits.The European journal of neuroscience · 2026Article
- Altered theta band and theta/beta ratio in mismatch negativity associate with treatment effect in schizophrenia with auditory hallucinations.Schizophrenia research. Cognition · 2025Article
- Differing Pattern of Mismatch Negativity Responses in Clinical and Nonclinical Voice Hearers Challenge Predictive Coding Accounts of Psychosis.Biological psychiatry global open science · 2025Article
- Automatic sensory change processing in adults with attention deficit and hyperactivity disorder: a visual mismatch negativity study.European archives of psychiatry and clinical neuroscience · 2024Article
- Contingent negative variation as an evaluation indicator of neurocognitive disorder after traumatic brain injury.Frontiers in psychiatry · 2023Article
Corrections and comments
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Authors and funding
6 authors.
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Abstract
backgroundMismatch negativity (MMN) amplitude is reduced in psychotic disorders and associated with symptoms and functioning. Due to these robust associations, it is often considered a biomarker for psychotic illness. The relationship between MMN and clinical outcomes has been examined well in early onset psychotic illness; however, its stability and predictive utility in chronic samples are not clear.
methodWe examined the five-year stability of MMN amplitude over two timepoints in individuals with established psychotic disorders (cases;
resultsMMN amplitude exhibited good temporal stability (cases,
conclusionsThese results imply that MMN measures a neural deficit that is reasonably stable up to five years. Results support disordered cognition and negative symptoms as preceding reduced MMN, which then may operate as a mechanism driving reductions in everyday functioning and the worsening of auditory hallucinations in chronic psychotic disorders. This pattern may inform models of illness course, clarifying the relationships amongst biological mechanisms of predictive processing and clinical deficits in chronic psychosis and allowing us to better understand the mechanisms driving such impairments over time.
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