Evidence map›Paper›PMID 36226529›Full record

ArticlePediatric endocrinology, diabetes, and metabolism2022

Vitamin D receptor gene polymorphisms in chronic kidney disease Egyptian children: effect on biochemical markers of bone mineral disorders.

Manal F Elshamaa, Eman Eryan, Hanan Hamed, Iman Khalifa, Solaf Kamel, Mona H Ibrahim, Dina Kandil, Hebatallah Farouk, Mona Raafat, Dalia A Abd-El Haleem and 5 more

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Article in Pediatric endocrinology, diabetes, and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Manal F ElshamaaPediatrics Department, National Research Centre, Cairo, Egypt.
Eman EryanPediatrics Department, Cairo University, Cairo, Egypt.
Hanan HamedPediatrics Department, Cairo University, Cairo, Egypt.
Iman KhalifaPediatrics Department, Cairo University, Cairo, Egypt.
Solaf KamelClinical Pathology Department, National Research Centre, Cairo, Egypt.
Mona H IbrahimClinical Pathology Department, National Research Centre, Cairo, Egypt.
Dina KandilClinical Pathology Department, National Research Centre, Cairo, Egypt.
Hebatallah FaroukClinical Pathology Department, National Research Centre, Cairo, Egypt.
Mona RaafatClinical Pathology Department, National Research Centre, Cairo, Egypt.
Dalia A Abd-El HaleemClinical Pathology Department, National Research Centre, Cairo, Egypt.
Eman MahmoudClinical Pathology Department, National Research Centre, Cairo, Egypt.
Gamila El-SaeedDepartment of Medical Biochemistry, National Research Centre, Cairo, Egypt.
Maha Abo HashishPediatrics Department, National Research Centre, Cairo, Egypt.
Enas Abd ElhamidPediatrics Department, National Research Centre, Cairo, Egypt.
Shaimaa SayedPediatrics Department, Cairo University, Cairo, Egypt.
National Research Centre · EGCairo University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe aim of this study was to assess the association between four vitamin D receptor (VDR) single nucleotide polymorphisms BsmI (rs1544410), ApaI (rs7975232), FokI (rs2228570) and TaqI (rs731236) and the susceptibility to chronic kidney disease (CKD) in Egyptian children and to evaluate their association with mineral status in these patients. MATERIAL AND

methodsThe current study included 305 patients with CKD and 100 apparently healthy children. We measured the serum vitamin D (VD), para-thyroid hormone (PTH) level and fibroblast growth factor 23 (FGF-23) levels by ELISA method. The genotyping of the four VDR gene variants was carried out by PCR-RFLP technique.

resultsThe TaqI AG & the BsmI TT genotypes were associated with a significantly higher risk of CKD. The expression of 25-OH D serum level was decreased in patients with TaqI GG & AG genotypes groups and in patients with BsmI TT genotype group The expression of PTH serum level was increased in patients with BsmI CT genotype group. The expression of FGF-23 serum level was increased in patients with Taq1 AG genotype group. We found 3 specific haplotypes; AGCA, AGCC and GGCA for healthy controls.

conclusionsOur study showed an association between VDR TaqI, BsmI polymorphisms and the susceptibility to CKD. The existence of VDR vari-ants affected the protein expression of VD, FGF-23 and PTH. The AGCA, AGCC and GGCA haplotypes were considered as protec-tive factors against the development of renal nephropathy in our population.

Indexed as

Receptors, CalcitriolRenal Insufficiency, ChronicBiomarkersChildEgyptFibroblast Growth FactorsGenetic Predisposition to DiseaseHumansMineralsPolymorphism, Single NucleotideVitamin DBiomarkersFibroblast Growth FactorsMineralsReceptors, CalcitriolVitamin Dchildrenchronic kidney diseasesecondary hyperparathyroidismVDR polymorphisms

Identifiers

PMID36226529
PMCPMC10214938
OpenAlexW4306168026

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.