Evidence map›Paper›PMID 36226184›Full record

ArticleFrontiers in genetics2022

Leader gene identification for digestive system cancers based on human subcellular location and cancer-related characteristics in protein-protein interaction networks.

Hongwei Chen, Zherou Rong, Luanfeng Ge, Hongzheng Yu, Chao Li, Manyi Xu, Zihan Zhang, Junjie Lv, Yuehan He, Wan Li and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Hongwei ChenCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Zherou RongCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Luanfeng GeCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Hongzheng YuCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Chao LiCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Manyi XuCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Zihan ZhangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Junjie LvCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Yuehan HeCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Wan LiCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Lina ChenCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Harbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stomach, liver, and colon cancers are the most common digestive system cancers leading to mortality. Cancer leader genes were identified in the current study as the genes that contribute to tumor initiation and could shed light on the molecular mechanisms in tumorigenesis. An integrated procedure was proposed to identify cancer leader genes based on subcellular location information and cancer-related characteristics considering the effects of nodes on their neighbors in human protein-protein interaction networks. A total of 69, 43, and 64 leader genes were identified for stomach, liver, and colon cancers, respectively. Furthermore, literature reviews and experimental data including protein expression levels and independent datasets from other databases all verified their association with corresponding cancer types. These final leader genes were expected to be used as diagnostic biomarkers and targets for new treatment strategies. The procedure for identifying cancer leader genes could be expanded to open up a window into the mechanisms, early diagnosis, and treatment of other cancer types.

Indexed as

cancer leader genecancer-related characteristicsdigestive system cancerprotein–protein interaction networksubcellular location

Identifiers

PMID36226184
PMCPMC9548996
OpenAlexW4297236819

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.