Evidence map›Paper›PMID 36226173›Full record

ArticleFrontiers in genetics2022

SARS-CoV-2 coinfections with variant genomic lineages identified by multiplex fragment analysis.

Richard Lueking, Andrew E Clark, Madhusudhanan Narasimhan, Lenin Mahimainathan, Alagarraju Muthukumar, Christian P Larsen, Jeffrey A SoRelle

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Analysis of spike protein variants evolved in a novelFrontiers in cellular and infection microbiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Richard LuekingDepartment of Internal Medicine, Division of Infectious Diseases and Geographic Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Andrew E ClarkDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Madhusudhanan NarasimhanDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Lenin MahimainathanDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Alagarraju MuthukumarDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Christian P LarsenDepartment of Internal Medicine, Division of Infectious Diseases and Geographic Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Jeffrey A SoRelleDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, United States.
The University of Texas Southwestern Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunocompromised patients can experience prolonged SARS-CoV-2 infections in the setting of a lack of protectivity immunity despite vaccination. As circulating SARS-CoV-2 strains become more heterogeneous, concomitant infection with multiple SARS-CoV-2 variants has become an increasing concern. Immunocompromised patient populations represent potential reservoirs for the emergence of novel SARS-CoV-2 variants through mutagenic change or coinfection followed by recombinatory events. Identification of SARS-CoV-2 coinfections is challenging using traditional next generation sequencing pipelines; however, targeted genotyping approaches can facilitate detection. Here we describe five COVID-19 cases caused by coinfection with different SARS-CoV-2 variants (Delta/Omicron BA.1 and Omicron BA.1/BA.2) as identified by multiplex fragment analysis.

Indexed as

co-infectionCOVID-19fragment analysismultiplex (RT)-PCRomicronSARS-CoV-2variant

Identifiers

PMID36226173
PMCPMC9549124
OpenAlexW4297229185

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.